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• W1603068052 abstract "The effect of adding various Na+, K+ and Li+ salts was tested on the adenylate cyclase activity present in pig-kidney-medulla plasma membranes. Salts were found to exert dual effects: stimulation at lowest doses and inhibition at highest doses. The importance of the stimulatory effect depended on the addition of NaF, hormone or guanylyl 5′-imidodiphosphate (GMP-P(NH)P) in the incubation medium. In all cases, maximum effect (2–3.4-fold increase in activity) was observed in the presence of saturating amounts of (8-lysine)vasopressin. Rate of adenylate cyclase activation by GMP-P(NH)P was enhanced in the presence of salt. Basal adenylate cyclase activity stimulation by salt was highly dependent on the nature of the salt used. There was a 10% increase with NaSCN and a 210% increase with NaCl. The effects of salts could not be accounted for by a fluoride-like effect. Among all the tested salts, only lithium salts inhibited hormone-stimulated enzyme. The order of potency, Li+, Na+, K+, was found when considering the inhibitory effect observed with high salt concentrations. For anions, the stimulatory effect observed with low salt concentration was I−, SCN−, Br−, Cl−, N−3, NO−3, HCOO− and CH3COO− in decreasing order of potency. Stimulatory effect of salt was observed when tested at 30 °C while highly inhibitory effect occurred at low temperature. Above 20 °C the energies of activation (Ea) were identical regardless of the presence of salt. At lower temperature, Ea was doubled in the presence of salt. All the stimulatory salts did not change the characteristics of adenylate cyclase activation by (8-lysine)vasopressin or its analogues, but stimulation ratio was enhanced. The above results cannot be entirely accounted for by a chaotropic action of ions on the membrane structure." @default.
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• W1603068052 date "1977-09-01" @default.
• W1603068052 modified "2023-10-16" @default.
• W1603068052 title "Vasopressin-Sensitive Kidney Adenylate Cyclase. Differential Effects of Monovalent Ions on Stimulation by Fluoride, Vasopressin and Guanylyl 5'-imidodiphosphate" @default.
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• W1603068052 doi "https://doi.org/10.1111/j.1432-1033.1977.tb11743.x" @default.
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