Matches in SemOpenAlex for { <https://semopenalex.org/work/W1603103625> ?p ?o ?g. }
- W1603103625 endingPage "18873" @default.
- W1603103625 startingPage "18866" @default.
- W1603103625 abstract "Transcription of the ornithine decarboxylase (ODC) gene is rapidly elevated by activation of protein kinase A (PKA). The additive influence of three cis-acting elements is responsible for this regulation in an adrenal carcinoma cell line. Two sites, CRE2 at -48 base pairs (bp) relative to the start of transcription and CRE3 at +95 bp, are identical to the core motif of the cAMP-responsive element (CRE) of the somatostatin gene and are conserved in the mouse, rat, and human ODC genes. Mutation of CRE2 resulted in a substantial decrease in basal promoter activity, as well as a 5-fold decrease in inducibility of the ODC promoter by PKA. CRE3 did not contribute to the basal activity of the ODC promoter, but mutation of this site resulted in a 2-fold decrease in inducibility by PKA. Deletion of a 45-bp sequence (GC-box) located 5' of CRE2, also resulted in a 2-fold decrease in inducibility of the ODC promoter. DNase I protection revealed the presence of protein binding at CRE2, the TATA box, and the GC-box of the ODC promoter. Mutation of CRE2 resulted in loss of protection of this sequence, as well as the 3' extension of the footprint over the TATA box, without affecting interactions at the GC box. Antibodies to the well characterized CRE-binding protein CREB recognized proteins binding to CRE2, suggesting that binding of CREB, or an antigenically related protein, is important for the activity of CRE2. Additionally, recombinant CREB bound to a DNA probe containing the CRE2 sequence." @default.
- W1603103625 created "2016-06-24" @default.
- W1603103625 creator A5042141022 @default.
- W1603103625 creator A5065157689 @default.
- W1603103625 creator A5069241812 @default.
- W1603103625 creator A5073512831 @default.
- W1603103625 date "1992-09-01" @default.
- W1603103625 modified "2023-10-05" @default.
- W1603103625 title "Multiple DNA elements responsible for transcriptional regulation of the ornithine decarboxylase gene by protein kinase A." @default.
- W1603103625 cites W1490560449 @default.
- W1603103625 cites W1496546960 @default.
- W1603103625 cites W150716091 @default.
- W1603103625 cites W1508697958 @default.
- W1603103625 cites W1525853704 @default.
- W1603103625 cites W1553990168 @default.
- W1603103625 cites W1564556915 @default.
- W1603103625 cites W1564741789 @default.
- W1603103625 cites W1569934864 @default.
- W1603103625 cites W1574907524 @default.
- W1603103625 cites W1575011694 @default.
- W1603103625 cites W1576381397 @default.
- W1603103625 cites W1584373876 @default.
- W1603103625 cites W1586437812 @default.
- W1603103625 cites W1596645541 @default.
- W1603103625 cites W1598530978 @default.
- W1603103625 cites W1604461344 @default.
- W1603103625 cites W1607257501 @default.
- W1603103625 cites W1613957108 @default.
- W1603103625 cites W1614984317 @default.
- W1603103625 cites W1783564941 @default.
- W1603103625 cites W1964623084 @default.
- W1603103625 cites W1967004332 @default.
- W1603103625 cites W1969332794 @default.
- W1603103625 cites W1970013273 @default.
- W1603103625 cites W1973135307 @default.
- W1603103625 cites W1974014686 @default.
- W1603103625 cites W1974034312 @default.
- W1603103625 cites W197438496 @default.
- W1603103625 cites W1989026677 @default.
- W1603103625 cites W1993644340 @default.
- W1603103625 cites W1994393699 @default.
- W1603103625 cites W1996251138 @default.
- W1603103625 cites W2000324336 @default.
- W1603103625 cites W2004174427 @default.
- W1603103625 cites W2004917770 @default.
- W1603103625 cites W2021253208 @default.
- W1603103625 cites W2022184895 @default.
- W1603103625 cites W2038218774 @default.
- W1603103625 cites W2038962047 @default.
- W1603103625 cites W2041208268 @default.
- W1603103625 cites W2041639550 @default.
- W1603103625 cites W2042976701 @default.
- W1603103625 cites W2045467759 @default.
- W1603103625 cites W2048180296 @default.
- W1603103625 cites W2050281571 @default.
- W1603103625 cites W2051586659 @default.
- W1603103625 cites W2059358614 @default.
- W1603103625 cites W2062250423 @default.
- W1603103625 cites W2064856877 @default.
- W1603103625 cites W2074997738 @default.
- W1603103625 cites W2085942332 @default.
- W1603103625 cites W2100025889 @default.
- W1603103625 cites W2109399660 @default.
- W1603103625 cites W2112365969 @default.
- W1603103625 cites W2127167523 @default.
- W1603103625 cites W2165151174 @default.
- W1603103625 cites W4238270754 @default.
- W1603103625 cites W4294216491 @default.
- W1603103625 doi "https://doi.org/10.1016/s0021-9258(19)37041-3" @default.
- W1603103625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1356108" @default.
- W1603103625 hasPublicationYear "1992" @default.
- W1603103625 type Work @default.
- W1603103625 sameAs 1603103625 @default.
- W1603103625 citedByCount "43" @default.
- W1603103625 countsByYear W16031036252013 @default.
- W1603103625 countsByYear W16031036252021 @default.
- W1603103625 countsByYear W16031036252022 @default.
- W1603103625 crossrefType "journal-article" @default.
- W1603103625 hasAuthorship W1603103625A5042141022 @default.
- W1603103625 hasAuthorship W1603103625A5065157689 @default.
- W1603103625 hasAuthorship W1603103625A5069241812 @default.
- W1603103625 hasAuthorship W1603103625A5073512831 @default.
- W1603103625 hasBestOaLocation W16031036251 @default.
- W1603103625 hasConcept C104317684 @default.
- W1603103625 hasConcept C108905728 @default.
- W1603103625 hasConcept C121289238 @default.
- W1603103625 hasConcept C153911025 @default.
- W1603103625 hasConcept C181199279 @default.
- W1603103625 hasConcept C184235292 @default.
- W1603103625 hasConcept C185592680 @default.
- W1603103625 hasConcept C54355233 @default.
- W1603103625 hasConcept C552990157 @default.
- W1603103625 hasConcept C55493867 @default.
- W1603103625 hasConcept C86803240 @default.
- W1603103625 hasConcept C95444343 @default.
- W1603103625 hasConcept C97029542 @default.
- W1603103625 hasConceptScore W1603103625C104317684 @default.
- W1603103625 hasConceptScore W1603103625C108905728 @default.