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• W1603250162 abstract "The zebrafish (Danio rerio) is an established model organism for the study of developmental processes, human disease, and tissue regeneration. We report that limb regeneration is severely impaired in our newly developed adult zebrafish model of type I diabetes mellitus. Intraperitoneal streptozocin injection of adult, wild-type zebrafish results in a sustained hyperglycemic state as determined by elevated fasting blood glucose values and increased glycation of serum protein. Serum insulin levels are also decreased and pancreas immunohistochemisty revealed a decreased amount of insulin signal in hyperglycemic fish. Additionally, the diabetic complications of retinal thinning and glomerular basement membrane thickening (early signs of retinopathy and nephropathy) resulting from the hyperglycemic state were evident in streptozocin-injected fish at 3 weeks. Most significantly, limb regeneration, following caudal fin amputation, is severely impaired in diabetic zebrafish and nonspecific toxic effects outside the pancreas were not found to contribute to impaired limb regeneration. This experimental system using adult zebrafish facilitates a broad spectrum of genetic and molecular approaches to study regeneration in the diabetic background." @default.
• W1603250162 created "2016-06-24" @default.
• W1603250162 creator A5008121982 @default.
• W1603250162 creator A5013638380 @default.
• W1603250162 creator A5057417129 @default.
• W1603250162 date "2010-09-14" @default.
• W1603250162 modified "2023-09-30" @default.
• W1603250162 title "Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus" @default.
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• W1603250162 doi "https://doi.org/10.1111/j.1524-475x.2010.00613.x" @default.
• W1603250162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2941236" @default.
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