FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1603358246> ?p ?o ?g. }

• W1603358246 endingPage "1441" @default.
• W1603358246 startingPage "1435" @default.
• W1603358246 abstract "The aim of this study was to investigate the relationship between plasma coenzyme Q10 (CoQ10) and survival in patients with chronic heart failure (CHF). Patients with CHF have low plasma concentrations of CoQ10, an essential cofactor for mitochondrial electron transport and myocardial energy supply. Additionally, low plasma total cholesterol (TC) concentrations have been associated with higher mortality in heart failure. Plasma CoQ10 is closely associated with low-density lipoprotein cholesterol (LDL-C), which might contribute to this association. Therefore we tested the hypothesis that plasma CoQ10 is a predictor of total mortality in CHF and could explain this association. Plasma samples from 236 patients admitted to the hospital with CHF, with a median (range) duration of follow-up of 2.69 (0.12 to 5.75) years, were assayed for LDL-C, TC, and total CoQ10. Median age at admission was 77 years. Median (range) CoQ10 concentration was 0.68 (0.18 to 1.75) μmol/l. The optimal CoQ10 concentration for prediction of mortality (established with receiver-operator characteristic [ROC] curves) was 0.73 μmol/l. Multivariable analysis allowing for effects of standard predictors of survival—including age at admission, gender, previous myocardial infarction, N-terminal peptide of B-type natriuretic peptide, and estimated glomerular filtration rate (modification of diet in renal disease)—indicated CoQ10 was an independent predictor of survival, whether dichotomized at the ROC curve cut-point (hazard ratio [HR]: 2.0; 95% confidence interval [CI]: 1.2 to 3.3) or the median (HR: 1.6; 95% CI: 1.0 to 2.6). Plasma CoQ10 concentration was an independent predictor of mortality in this cohort. The CoQ10 deficiency might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with CoQ10." @default.
• W1603358246 created "2016-06-24" @default.
• W1603358246 creator A5020199989 @default.
• W1603358246 creator A5031262573 @default.
• W1603358246 creator A5038923266 @default.
• W1603358246 creator A5057066767 @default.
• W1603358246 creator A5074639486 @default.
• W1603358246 creator A5076204869 @default.
• W1603358246 creator A5087066089 @default.
• W1603358246 date "2008-10-01" @default.
• W1603358246 modified "2023-10-16" @default.
• W1603358246 title "Coenzyme Q10" @default.
• W1603358246 cites W1525616846 @default.
• W1603358246 cites W1541324572 @default.
• W1603358246 cites W1930777280 @default.
• W1603358246 cites W1968114517 @default.
• W1603358246 cites W1969398411 @default.
• W1603358246 cites W1974451585 @default.
• W1603358246 cites W1976069407 @default.
• W1603358246 cites W2015452872 @default.
• W1603358246 cites W2015991505 @default.
• W1603358246 cites W2021509793 @default.
• W1603358246 cites W2028389960 @default.
• W1603358246 cites W2036778165 @default.
• W1603358246 cites W2041490141 @default.
• W1603358246 cites W2049348368 @default.
• W1603358246 cites W2055864845 @default.
• W1603358246 cites W2059930169 @default.
• W1603358246 cites W2068948766 @default.
• W1603358246 cites W2071098701 @default.
• W1603358246 cites W2079171902 @default.
• W1603358246 cites W2086578266 @default.
• W1603358246 cites W2095944884 @default.
• W1603358246 cites W2106936194 @default.
• W1603358246 cites W2114445117 @default.
• W1603358246 cites W2126452437 @default.
• W1603358246 cites W2128400971 @default.
• W1603358246 cites W2189283745 @default.
• W1603358246 cites W4210427144 @default.
• W1603358246 doi "https://doi.org/10.1016/j.jacc.2008.07.044" @default.
• W1603358246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017509" @default.
• W1603358246 hasPublicationYear "2008" @default.
• W1603358246 type Work @default.
• W1603358246 sameAs 1603358246 @default.
• W1603358246 citedByCount "177" @default.
• W1603358246 countsByYear W16033582462012 @default.
• W1603358246 countsByYear W16033582462013 @default.
• W1603358246 countsByYear W16033582462014 @default.
• W1603358246 countsByYear W16033582462015 @default.
• W1603358246 countsByYear W16033582462016 @default.
• W1603358246 countsByYear W16033582462017 @default.
• W1603358246 countsByYear W16033582462018 @default.
• W1603358246 countsByYear W16033582462019 @default.
• W1603358246 countsByYear W16033582462020 @default.
• W1603358246 countsByYear W16033582462021 @default.
• W1603358246 countsByYear W16033582462022 @default.
• W1603358246 countsByYear W16033582462023 @default.
• W1603358246 crossrefType "journal-article" @default.
• W1603358246 hasAuthorship W1603358246A5020199989 @default.
• W1603358246 hasAuthorship W1603358246A5031262573 @default.
• W1603358246 hasAuthorship W1603358246A5038923266 @default.
• W1603358246 hasAuthorship W1603358246A5057066767 @default.
• W1603358246 hasAuthorship W1603358246A5074639486 @default.
• W1603358246 hasAuthorship W1603358246A5076204869 @default.
• W1603358246 hasAuthorship W1603358246A5087066089 @default.
• W1603358246 hasConcept C126322002 @default.
• W1603358246 hasConcept C134018914 @default.
• W1603358246 hasConcept C159641895 @default.
• W1603358246 hasConcept C164705383 @default.
• W1603358246 hasConcept C207103383 @default.
• W1603358246 hasConcept C2775915353 @default.
• W1603358246 hasConcept C2778198053 @default.
• W1603358246 hasConcept C2779384338 @default.
• W1603358246 hasConcept C44249647 @default.
• W1603358246 hasConcept C500558357 @default.
• W1603358246 hasConcept C58471807 @default.
• W1603358246 hasConcept C71924100 @default.
• W1603358246 hasConcept C76318530 @default.
• W1603358246 hasConcept C90924648 @default.
• W1603358246 hasConceptScore W1603358246C126322002 @default.
• W1603358246 hasConceptScore W1603358246C134018914 @default.
• W1603358246 hasConceptScore W1603358246C159641895 @default.
• W1603358246 hasConceptScore W1603358246C164705383 @default.
• W1603358246 hasConceptScore W1603358246C207103383 @default.
• W1603358246 hasConceptScore W1603358246C2775915353 @default.
• W1603358246 hasConceptScore W1603358246C2778198053 @default.
• W1603358246 hasConceptScore W1603358246C2779384338 @default.
• W1603358246 hasConceptScore W1603358246C44249647 @default.
• W1603358246 hasConceptScore W1603358246C500558357 @default.
• W1603358246 hasConceptScore W1603358246C58471807 @default.
• W1603358246 hasConceptScore W1603358246C71924100 @default.
• W1603358246 hasConceptScore W1603358246C76318530 @default.
• W1603358246 hasConceptScore W1603358246C90924648 @default.
• W1603358246 hasIssue "18" @default.
• W1603358246 hasLocation W16033582461 @default.
• W1603358246 hasLocation W16033582462 @default.
• W1603358246 hasOpenAccess W1603358246 @default.
• W1603358246 hasPrimaryLocation W16033582461 @default.

• next