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- W1603421388 abstract "Summary. Prophylactic treatment with human granulocyte colony‐stimulating factor (hG‐CSF) affords significant protection against systemic aspergillosis or pulmonary aspergillosis in neutropenic (cyclophosphamid‐treated) mice but not in cortisone‐treated animals. Cryptococcosis does not respond to hG‐CSF therapy. Our data show that granulocytes play an important role in the immune defense against aspergillosis, but not against cryptococcosis. Combined treatment using hG‐CSF and conventional antimycotics shows a significant beneficial effect in systemic or pulmonary aspergillosis. Zusammenfassung. Die prophylaktische Be‐handlung mit dem granulozytenstimulierenden Faktor des Menschen (hG‐CSF) gewährt signifi‐kanten Schutz gegen die tieflokalisierte Aspergillose und die Lungen‐Aspergillose an neutropenischen, Cyclophosphamid‐behandelten Mäusen, nicht je‐doch an Cortison‐behandelten Tieren. Die Cryp‐tococcose spricht auf hG‐CSF‐Therapie nicht an. Unsere Ergebnisse zeigen, daß Granulozyten eine wichtige Rolle in der Immunabwehr der Aspergil‐lose, nicht jedoch der Cryptococcose spielen. Die Kombinationsbehandlung mit hG‐CSF und kon‐ventionellen Antimykotika zeigte eine signifikante günstige Wirkung auf die sytemische wie auf die Lungen‐Aspergillose." @default.
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- W1603421388 date "1991-05-01" @default.
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- W1603421388 title "Protective effect of human granulocyte colony‐stimulating factor (hG‐CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice" @default.
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- W1603421388 doi "https://doi.org/10.1111/j.1439-0507.1991.tb00645.x" @default.
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