FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1603668555> ?p ?o ?g. }

• W1603668555 abstract "The pathogenesis of autoimmune diseases remains largely obscure despite extensive research. The role of triggering factors in the onset is unquestionable. However, at present, the focus of research lies in the mechanisms that locally control immune responses. Especially, enforcing the induction of regulatory T cells by self-antigens that are involved in the ongoing inflammation opens the way for new forms of specific immunotherapy. In this thesis, we aimed at exploring the mechanisms related to the ongoing inflammation in juvenile dermatomyositis (JDM) as a model for autoimmune disease. JDM is a multisystem inflammatory disease that involves primarily the muscle and skin, but may affect many other systems We describe the spectrum of the disease, with emphasis on indicators for disease prognosis and new instruments to evaluate disease activity. These parameters are warranted for optimal choice of treatment regimens. Because disease prognosis and disease activity are correlated with the extent of the inflammatory process, underlying immunological mechanisms contributing to disease were analyzed. We focussed on regulatory T cells (Treg) as main players in peripheral tolerance. We were able to describe the characteristics of Treg in JDM and found possible clues pointing at impaired Treg function. The selection of heat shock proteins (HSP) as the self-antigens possibly involved in the inflammatory process was made because of their specific characteristics and because of the results of previous research in other autoimmune diseases. We showed that HSP60 and HSP60 epitopes can induce T cell regulation in vitro in JDM. In this disease, to our knowledge, no previous studies on these subjects were presented. Interestingly, HSP70 did not seem to induce adaptive immune responses. On the other hand, overexpression of HSP70 at the inflammatory site can be regarded as a sign of protection against further damage. Because immune reactivity to the HSP60 epitopes is also demonstrated in other autoimmune diseases, these epitopes could be related to inflammation in general and thus be applied in a broader patient population. T cell responses to HSP60 epitopes could also be used as biomarkers for disease activity and prognosis or for follow-up of future immunotherapy studies with epitopes. Altogether, this thesis offers intriguing new insights in the pathogenesis of an autoimmune disease that lacks an adequate animal model for thorough research. It is of importance to confirm our findings in a larger group of JDM patients which, because of the rarity of these diseases, necessitates a multicenter approach." @default.
• W1603668555 created "2016-06-24" @default.
• W1603668555 creator A5017140758 @default.
• W1603668555 date "2007-04-19" @default.
• W1603668555 modified "2023-09-27" @default.
• W1603668555 title "Unravelling disease mechanisms in juvenile dermatomyositis" @default.
• W1603668555 cites W1486722793 @default.
• W1603668555 cites W1500134182 @default.
• W1603668555 cites W1507624196 @default.
• W1603668555 cites W1517570604 @default.
• W1603668555 cites W1579431146 @default.
• W1603668555 cites W1753521056 @default.
• W1603668555 cites W1880539088 @default.
• W1603668555 cites W1965815841 @default.
• W1603668555 cites W1968798526 @default.
• W1603668555 cites W1969370052 @default.
• W1603668555 cites W1979527652 @default.
• W1603668555 cites W1980016917 @default.
• W1603668555 cites W1980752022 @default.
• W1603668555 cites W1984597382 @default.
• W1603668555 cites W1987835016 @default.
• W1603668555 cites W1991600170 @default.
• W1603668555 cites W1991823448 @default.
• W1603668555 cites W1992139204 @default.
• W1603668555 cites W1992790199 @default.
• W1603668555 cites W1997379610 @default.
• W1603668555 cites W1997723053 @default.
• W1603668555 cites W2006336879 @default.
• W1603668555 cites W2007380696 @default.
• W1603668555 cites W2007439753 @default.
• W1603668555 cites W2007606955 @default.
• W1603668555 cites W2010594819 @default.
• W1603668555 cites W2012607782 @default.
• W1603668555 cites W2013289639 @default.
• W1603668555 cites W2014344382 @default.
• W1603668555 cites W2016237110 @default.
• W1603668555 cites W2018271514 @default.
• W1603668555 cites W2023669188 @default.
• W1603668555 cites W2026657673 @default.
• W1603668555 cites W2032646952 @default.
• W1603668555 cites W2036260827 @default.
• W1603668555 cites W2040693525 @default.
• W1603668555 cites W2044644799 @default.
• W1603668555 cites W2049521998 @default.
• W1603668555 cites W2054626405 @default.
• W1603668555 cites W2058095634 @default.
• W1603668555 cites W2058230154 @default.
• W1603668555 cites W2065619967 @default.
• W1603668555 cites W2069456329 @default.
• W1603668555 cites W2070356198 @default.
• W1603668555 cites W2081672265 @default.
• W1603668555 cites W2083237508 @default.
• W1603668555 cites W2086677328 @default.
• W1603668555 cites W2087186637 @default.
• W1603668555 cites W2090038697 @default.
• W1603668555 cites W2097052442 @default.
• W1603668555 cites W2098479780 @default.
• W1603668555 cites W2100369434 @default.
• W1603668555 cites W2103097055 @default.
• W1603668555 cites W2107480668 @default.
• W1603668555 cites W2111457140 @default.
• W1603668555 cites W2115784025 @default.
• W1603668555 cites W2118268169 @default.
• W1603668555 cites W2121934956 @default.
• W1603668555 cites W2127052671 @default.
• W1603668555 cites W2134303883 @default.
• W1603668555 cites W2136153888 @default.
• W1603668555 cites W2140080251 @default.
• W1603668555 cites W2141416163 @default.
• W1603668555 cites W2141989396 @default.
• W1603668555 cites W2143045744 @default.
• W1603668555 cites W2144652377 @default.
• W1603668555 cites W2147671004 @default.
• W1603668555 cites W2148331882 @default.
• W1603668555 cites W2149392845 @default.
• W1603668555 cites W2162348800 @default.
• W1603668555 cites W2170050529 @default.
• W1603668555 cites W2314311014 @default.
• W1603668555 cites W2329874676 @default.
• W1603668555 cites W2422065022 @default.
• W1603668555 cites W199823044 @default.
• W1603668555 hasPublicationYear "2007" @default.
• W1603668555 type Work @default.
• W1603668555 sameAs 1603668555 @default.
• W1603668555 citedByCount "0" @default.
• W1603668555 crossrefType "dissertation" @default.
• W1603668555 hasAuthorship W1603668555A5017140758 @default.
• W1603668555 hasConcept C104317684 @default.
• W1603668555 hasConcept C142724271 @default.
• W1603668555 hasConcept C146621620 @default.
• W1603668555 hasConcept C147483822 @default.
• W1603668555 hasConcept C159654299 @default.
• W1603668555 hasConcept C203014093 @default.
• W1603668555 hasConcept C205260736 @default.
• W1603668555 hasConcept C2776914184 @default.
• W1603668555 hasConcept C2777701055 @default.
• W1603668555 hasConcept C2778552304 @default.
• W1603668555 hasConcept C2779075594 @default.
• W1603668555 hasConcept C2779134260 @default.
• W1603668555 hasConcept C2780130043 @default.

• next