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- W1603669210 abstract "Treatment with prostaglandin E1 (PGE1) delays nephritis and death in NZB/W mice. In an effort to determine the effects of PGE1 on immune dysfunctions in NZB/W mice, spleen cell responses to phytohemagglutinin (PHA) and spleen lymphocyte numbers and proportions were compared in PGE1-treated and untreated NZB/W mice from 10 through 44 weeks of age. A sharp decline in both unstimulated and PHA-stimulated [3H]thymidine incorporation was observed in spleen cells from untreated mice older than 10 weeks. PGE1-treated mice maintained significantly higher unstimulated levels of [3H]thymidine incorporation than control mice from 13.5 through 44 weeks. Responses to PHA stimulation were consistently higher in cells from PGE1-treated than from untreated NZB/W mice until 28 weeks. Responses to PHA of spleen cells from both PGE1-treated and control NZB/W mice reflected their respective T- and B-cell concentrations. Splenomegaly was prevented, and the numbers of B and null cells were reduced by PGE1 treatment. Thus, although T-cell numbers were similar, the percentage of T cells in spleens from PGE1-treated mice was greater than in spleens from untreated NZB/W mice. Preservation of cell-mediated immunity may, therefore, reflect maintenance by PGE1 of appropriate T- and B-cell concentrations and may be one of the early mechanisms by which PGE1 alters the course of murine lupus." @default.
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- W1603669210 date "1978-11-01" @default.
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- W1603669210 title "Prostaglandin E1 treatment of NZB/W mice" @default.
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- W1603669210 doi "https://doi.org/10.1016/0090-1229(78)90049-1" @default.
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