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- W1603762456 abstract "textabstractTo obtain a better understanding of myocardial ischemia-reperfusion injury and toadvance therapeutical application of cardiac adaptation to ischemia, this thesis investigatesseveral mechanistic aspects of ischemic preconditioning with respect to triggers, mediators andpossible end-effectors.Adenosine is a well established trigger of ischemic preconditioning which is releasedduring ischemia as a breakdown product of ATP. At least four adenosine receptor subtypeshave been identified: A1-, A2a-, A2b- and A3- receptors.221 Both the A1- and the A3- receptorsubtypes are believed to trigger myocardial preconditioning.131·153·222 The cardioprotective roleof adenosine has been confirmed in all species used for experimental investigation.38 However,based on several studies using selective adenosine receptor antagonists which failed to blockischemic preconditioning, its role in rats is still controversial. 155•156 In these studies the durationof the ischemic stimuli were 3-5 min. Interestingly, Schulz et al. 133 demonstrated in the porcineheart that adenosine plays a significant role after 10-min of coronary artery occlusion.Therefore in chapter 2 we studied the role of adenosine in ischemic preconditioning in ratswith respect to the duration of the ischemic stimulus" @default.
- W1603762456 created "2016-06-24" @default.
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- W1603762456 date "2003-09-03" @default.
- W1603762456 modified "2023-09-27" @default.
- W1603762456 title "Mechanistic and therapeutic aspects of ischemic myocardial preconditioning" @default.
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