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- W1603804500 endingPage "55" @default.
- W1603804500 startingPage "23" @default.
- W1603804500 abstract "This chapter explores that cell differentiation involves drastic changes in cell metabolism. Thus, the synthesis of many proteins is stopped and that of new ones has begun. This type of regulation could be called macroregulation in contrast to microregulation, in which the synthesis of a particular protein, or set of proteins in an operon, is specifically regulated by induction and repression. The chapter deals with the possibility of tRNA involvement as a critical factor in cell differentiation at the macroregulation level. Various mechanisms for macroregulation can be visualized. The translation of mRNA into protein involves various components, such as ribosomes, initiation and termination factors, chain elongation factors, tRNA and aminoacyl-tRNA synthetase. Among these components for code translation, tRNA is the one most likely to be involved in macroregulation because of the unique feature of being multiple for each amino acid and yet ubiquitous for the synthesis of various proteins of the cell. Controls are likely to be operating at both levels. Degeneracy of the code and degeneracy of corresponding adaptors (tRNA) have been established. On the other hand, there is generally a single aminoacyl-tRNA synthetase for each amino acid in bacteria, although, some contradictory results have been reported. In higher organisms, the mitochondria1 system seems to have its own synthetases and tRNA's in addition to cytoplasmic synthetases and tRNA's." @default.
- W1603804500 created "2016-06-24" @default.
- W1603804500 creator A5020234789 @default.
- W1603804500 creator A5040544306 @default.
- W1603804500 date "1970-01-01" @default.
- W1603804500 modified "2023-09-25" @default.
- W1603804500 title "Transfer RNA and Cell Differentiation" @default.
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