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• W1604383845 abstract "Exfoliative cytology has been widely used for early diagnosis of oral squamous cell carcinoma (OSCC). Test outcome is reported as negative, atypical (defined as abnormal epithelial changes of uncertain diagnostic significance), and positive (defined as definitive cellular evidence of epithelial dysplasia or carcinoma). The major challenge is how to properly manage the atypical patients in order to diagnose OSCC early and prevent OSCC. In this study, we collected exfoliative cytology data, histopathology data, and clinical data of normal subjects (n=102), oral leukoplakia (OLK) patients (n=82), and OSCC patients (n=93), and developed a data analysis procedure for quantitative risk stratification of OLK patients. This procedure involving a step called expert-guided data transformation and reconstruction (EdTAR) which allows automatic data processing and reconstruction and reveals informative signals for subsequent risk stratification. Modern machine learning techniques were utilized to build statistical prediction models on the reconstructed data. Among the several models tested using resampling methods for parameter pruning and performance evaluation, Support Vector Machine (SVM) was found to be optimal with a high sensitivity (median>0.98) and specificity (median>0.99). With the SVM model, we constructed an oral cancer risk index (OCRI) which may potentially guide clinical follow-up of OLK patients. One OLK patient with an initial OCRI of 0.88 developed OSCC after 40 months of follow-up. In conclusion, we have developed a statistical method for qualitative risk stratification of OLK patients. This method may potentially improve cost-effectiveness of clinical follow-up of OLK patients, and help design clinical chemoprevention trial for high-risk populations." @default.
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• W1604383845 date "2015-05-15" @default.
• W1604383845 modified "2023-10-16" @default.
• W1604383845 title "Quantitative Risk Stratification of Oral Leukoplakia with Exfoliative Cytology" @default.
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• W1604383845 doi "https://doi.org/10.1371/journal.pone.0126760" @default.
• W1604383845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4433206" @default.
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• W1604383845 hasPublicationYear "2015" @default.
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