Matches in SemOpenAlex for { <https://semopenalex.org/work/W1604518097> ?p ?o ?g. }
- W1604518097 endingPage "52" @default.
- W1604518097 startingPage "245" @default.
- W1604518097 abstract "Many studies have been performed on the sarcoglycan sub-complex and a7B and b1D integrins, but their distribution and localization patterns along the non-junctional sarcolemma are still not clear. We have carried out an indirect immunofluorescence study on surgical biopsies of normal human skeletal muscle, performing double localization reactions with antibodies to sarcoglycans, integrins and sarcomeric actin. Our results indicate that the tested proteins colocalize with each other. In a few cases, a-sarcoglycan does not colocalize with the other sarcoglycans and integrins. We also demonstrated, by employing antibodies to all the tested proteins, that these proteins can be localized to regions of the sarcolemma corresponding either to the I-band or A-band. Our results seem to confirm the hypothesis of a correlation between the region of the sarcolemma occupied by costameric proteins and the metabolic type (fast or slow) of muscle fibers. On this basis, we suggest that slow fibers are characterized by localization of costameric proteins to I-bands, while fast fibers are characterized by localization of costameric proteins to A-bands. The results open a new line of research in understanding interactions between the components of the DGC and vinculin-talin-integrin complexes in the context of different fiber types. Moreover, the same results may be extended to skeletal muscle fibers affected by neuromuscular diseases to detect possible structural alterations." @default.
- W1604518097 created "2016-06-24" @default.
- W1604518097 creator A5027510427 @default.
- W1604518097 creator A5035172079 @default.
- W1604518097 creator A5045479227 @default.
- W1604518097 creator A5054925078 @default.
- W1604518097 creator A5057946299 @default.
- W1604518097 creator A5069889196 @default.
- W1604518097 creator A5072047244 @default.
- W1604518097 creator A5079960258 @default.
- W1604518097 creator A5083409753 @default.
- W1604518097 creator A5086062480 @default.
- W1604518097 date "2004-12-14" @default.
- W1604518097 modified "2023-09-23" @default.
- W1604518097 title "Sarcoglycan and integrin localization in normal human skeletal muscle: a confocal laser scanning microscope study." @default.
- W1604518097 cites W1561903693 @default.
- W1604518097 cites W186828966 @default.
- W1604518097 cites W1965336601 @default.
- W1604518097 cites W1969023545 @default.
- W1604518097 cites W1970253880 @default.
- W1604518097 cites W1971446783 @default.
- W1604518097 cites W1974745886 @default.
- W1604518097 cites W1979486745 @default.
- W1604518097 cites W1980243949 @default.
- W1604518097 cites W1981716920 @default.
- W1604518097 cites W1991201761 @default.
- W1604518097 cites W1993655674 @default.
- W1604518097 cites W1999512514 @default.
- W1604518097 cites W2003654592 @default.
- W1604518097 cites W2016761722 @default.
- W1604518097 cites W2018096072 @default.
- W1604518097 cites W2018922749 @default.
- W1604518097 cites W2024364295 @default.
- W1604518097 cites W2027390836 @default.
- W1604518097 cites W2031806916 @default.
- W1604518097 cites W2034544118 @default.
- W1604518097 cites W2039012502 @default.
- W1604518097 cites W2055883057 @default.
- W1604518097 cites W2057200625 @default.
- W1604518097 cites W2059130687 @default.
- W1604518097 cites W2067661389 @default.
- W1604518097 cites W2068659250 @default.
- W1604518097 cites W2072784433 @default.
- W1604518097 cites W2084162464 @default.
- W1604518097 cites W2092612142 @default.
- W1604518097 cites W2096810972 @default.
- W1604518097 cites W2096903107 @default.
- W1604518097 cites W2100652705 @default.
- W1604518097 cites W2106644177 @default.
- W1604518097 cites W2143513370 @default.
- W1604518097 cites W2146750755 @default.
- W1604518097 cites W2154729967 @default.
- W1604518097 cites W2167956058 @default.
- W1604518097 cites W2168918180 @default.
- W1604518097 cites W2170820559 @default.
- W1604518097 cites W2232303463 @default.
- W1604518097 cites W2320022870 @default.
- W1604518097 cites W2329473893 @default.
- W1604518097 cites W2436979730 @default.
- W1604518097 cites W69629398 @default.
- W1604518097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15590414" @default.
- W1604518097 hasPublicationYear "2004" @default.
- W1604518097 type Work @default.
- W1604518097 sameAs 1604518097 @default.
- W1604518097 citedByCount "6" @default.
- W1604518097 countsByYear W16045180972012 @default.
- W1604518097 countsByYear W16045180972016 @default.
- W1604518097 crossrefType "journal-article" @default.
- W1604518097 hasAuthorship W1604518097A5027510427 @default.
- W1604518097 hasAuthorship W1604518097A5035172079 @default.
- W1604518097 hasAuthorship W1604518097A5045479227 @default.
- W1604518097 hasAuthorship W1604518097A5054925078 @default.
- W1604518097 hasAuthorship W1604518097A5057946299 @default.
- W1604518097 hasAuthorship W1604518097A5069889196 @default.
- W1604518097 hasAuthorship W1604518097A5072047244 @default.
- W1604518097 hasAuthorship W1604518097A5079960258 @default.
- W1604518097 hasAuthorship W1604518097A5083409753 @default.
- W1604518097 hasAuthorship W1604518097A5086062480 @default.
- W1604518097 hasConcept C105702510 @default.
- W1604518097 hasConcept C1491633281 @default.
- W1604518097 hasConcept C151166631 @default.
- W1604518097 hasConcept C159654299 @default.
- W1604518097 hasConcept C181709278 @default.
- W1604518097 hasConcept C185592680 @default.
- W1604518097 hasConcept C195687474 @default.
- W1604518097 hasConcept C199096232 @default.
- W1604518097 hasConcept C203014093 @default.
- W1604518097 hasConcept C2777979848 @default.
- W1604518097 hasConcept C2778236600 @default.
- W1604518097 hasConcept C2779959927 @default.
- W1604518097 hasConcept C40209533 @default.
- W1604518097 hasConcept C55493867 @default.
- W1604518097 hasConcept C62478195 @default.
- W1604518097 hasConcept C86803240 @default.
- W1604518097 hasConcept C95444343 @default.
- W1604518097 hasConceptScore W1604518097C105702510 @default.
- W1604518097 hasConceptScore W1604518097C1491633281 @default.
- W1604518097 hasConceptScore W1604518097C151166631 @default.