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• W1604583062 startingPage "2223" @default.
• W1604583062 abstract "Protein C inhibitor (PCI; SERPINA5) is a plasma serine protease inhibitor, and a potent inhibitor of activated protein C (APC), which plays a critical role in the anticoagulant protein C pathway. Recently, PCI was also found to form a complex with the serine protease hepatocyte growth factor activator (HGFA), inhibiting the HGFA-catalyzed activation of the single-chain hepatocyte growth factor precursor. In vivo studies using human PCI-transgenic (hPCI-Tg) mice, which mimic PCI expression in humans, showed that the regeneration rate of the liver after partial hepatectomy was significantly impaired as compared with wild-type mice. The decreased liver regeneration in hPCI-Tg mice was restored by pretreatment with antibody against human PCI. Furthermore, APC protected hepatic nonparenchymal cells from thrombin-induced inflammation in vitro, suggesting that plasma PCI may inhibit the cytoprotective action of APC on hepatic cells in hPCI-Tg mice. It was shown that the levels of HGFA-PCI are increased in plasma of patients who have been subjected to hepatectomy, as compared with complex levels in the plasma of normal individuals. Thus, PCI may play a role as a potent inhibitor of HGFA and APC in plasma and/or at the sites of tissue injury in the regulation of tissue regeneration." @default.
• W1604583062 created "2016-06-24" @default.
• W1604583062 creator A5062405573 @default.
• W1604583062 date "2010-04-09" @default.
• W1604583062 modified "2023-10-03" @default.
• W1604583062 title "Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor" @default.
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• W1604583062 doi "https://doi.org/10.1111/j.1742-4658.2010.07639.x" @default.
• W1604583062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20402764" @default.
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