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- W1604591695 abstract "Smell acuity has been measured by many different methods using a variety of techniques and stimuli. The most clinically practical technique involves psychophysical measurement of smell acuity. Using this technique with signal detection, single or multiple stimuli or other methods it has been possible to distinguish subjects with normal smell function from those with smell loss (hyposmia). Using these traditional techniques measurements have been used to obtain sensory thresholds [detection (DT) and recognition (RT)] and estimates of magnitude estimation (ME). However, most investigators currently using these techniques have not established standards by which patient pathology can be defined either with respect to initial hyposmia or to changes on treatment. We have established standards for both normal subjects and patients with hyposmia and have used them to define both initial hyposmia and treatment efficacy. Type I hyposmia is defined by absent RT and ME but preservation of DT. Type II hyposmia is defined by decreased DT, RT and ME. With these parameters as a clinical basis 233 patients with smell loss were evaluated and then treated with the generalized phosphodiesterase inhibitor theophylline at daily doses of 200–1000 mg for 2–24 months. Results indicate that 40 % of patients with Type I hyposmia and 70 % of patients with Type II hyposmia demonstrated improved smell acuity. By use of these specific clinical measurements it is now possible to predict clinical outcome based upon initial hyposmia measurements. These results also demonstrate that measurement standards of olfactory acuity have now been established similar to standards measuring pathology of metabolic processes using blood or urine." @default.
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- W1604591695 date "2006-03-01" @default.
- W1604591695 modified "2023-09-27" @default.
- W1604591695 title "Measurement standards of smell acuity are necessary to define pathology and treatment of smell loss" @default.
- W1604591695 doi "https://doi.org/10.1096/fasebj.20.4.a381-a" @default.
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