FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1604663875> ?p ?o ?g. }

• W1604663875 endingPage "411" @default.
• W1604663875 startingPage "403" @default.
• W1604663875 abstract "Many active substances are poorly water-soluble and pose a great challenge when orally administered because drug bioavailability is largely dependent on its solubility.The objective of this investigation was to evaluate the effect of hydroxypropyl methylcellulose (HPMC) as an additive on the physical properties of spray-congealed polyethylene glycol (PEG) microparticles.The effects of four viscosity grades of HPMC (K100 LV, K4M, K15M and K100M) on the spray-congealing process yield and physical properties of spray-congealed microparticles, such as morphology and particle size, were studied. The swelling effect of HPMC on drug release was also explored using surface plots.Molten mixtures containing PEG and HPMC of various grades and concentrations were successfully spray-congealed with useful yield ranging from 42.6% to 58.4%. Smooth and spherical microparticles were produced and their size was found to increase with increasing feed viscosity. The swelling extent of microparticles was found to be influenced by the grade, particle size and amount of HPMC present while the rate of erosion depended on the formation of the barrier and grade of HPMC used. Formulations with appropriate rates of erosion were selected to prepare microparticles with rifampicin (RIF), a poorly water-soluble drug. At 10% (w/w), K100 LV was found to enhance the dissolution of RIF while K15M retarded the release.The novel application of HPMC as an additive in spray-congealed PEG microparticles not only affected the physical properties of the microparticles but also modified the drug release by its swelling effect." @default.
• W1604663875 created "2016-06-24" @default.
• W1604663875 creator A5020074724 @default.
• W1604663875 creator A5020922729 @default.
• W1604663875 creator A5033860973 @default.
• W1604663875 creator A5050568819 @default.
• W1604663875 date "2015-07-13" @default.
• W1604663875 modified "2023-09-27" @default.
• W1604663875 title "Impact of HPMC on the physical properties of spray-congealed PEG microparticles and its swelling effect on rifampicin dissolution" @default.
• W1604663875 cites W1254534305 @default.
• W1604663875 cites W1498305210 @default.
• W1604663875 cites W197368718 @default.
• W1604663875 cites W1984725651 @default.
• W1604663875 cites W1998871511 @default.
• W1604663875 cites W2009539533 @default.
• W1604663875 cites W2012499755 @default.
• W1604663875 cites W2019316854 @default.
• W1604663875 cites W2019554934 @default.
• W1604663875 cites W2026312171 @default.
• W1604663875 cites W2037593395 @default.
• W1604663875 cites W2040865803 @default.
• W1604663875 cites W2053854213 @default.
• W1604663875 cites W2056904954 @default.
• W1604663875 cites W2058573692 @default.
• W1604663875 cites W2061100919 @default.
• W1604663875 cites W2065171656 @default.
• W1604663875 cites W2076903550 @default.
• W1604663875 cites W2082746084 @default.
• W1604663875 cites W2084610976 @default.
• W1604663875 cites W2101171473 @default.
• W1604663875 cites W2156829937 @default.
• W1604663875 cites W3217585462 @default.
• W1604663875 doi "https://doi.org/10.3109/03639045.2015.1061536" @default.
• W1604663875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26165248" @default.
• W1604663875 hasPublicationYear "2015" @default.
• W1604663875 type Work @default.
• W1604663875 sameAs 1604663875 @default.
• W1604663875 citedByCount "10" @default.
• W1604663875 countsByYear W16046638752016 @default.
• W1604663875 countsByYear W16046638752018 @default.
• W1604663875 countsByYear W16046638752019 @default.
• W1604663875 countsByYear W16046638752020 @default.
• W1604663875 countsByYear W16046638752021 @default.
• W1604663875 countsByYear W16046638752022 @default.
• W1604663875 countsByYear W16046638752023 @default.
• W1604663875 crossrefType "journal-article" @default.
• W1604663875 hasAuthorship W1604663875A5020074724 @default.
• W1604663875 hasAuthorship W1604663875A5020922729 @default.
• W1604663875 hasAuthorship W1604663875A5033860973 @default.
• W1604663875 hasAuthorship W1604663875A5050568819 @default.
• W1604663875 hasConcept C10138342 @default.
• W1604663875 hasConcept C127172972 @default.
• W1604663875 hasConcept C127413603 @default.
• W1604663875 hasConcept C155574463 @default.
• W1604663875 hasConcept C159985019 @default.
• W1604663875 hasConcept C162324750 @default.
• W1604663875 hasConcept C178790620 @default.
• W1604663875 hasConcept C181389837 @default.
• W1604663875 hasConcept C185592680 @default.
• W1604663875 hasConcept C187530423 @default.
• W1604663875 hasConcept C192562407 @default.
• W1604663875 hasConcept C2776964284 @default.
• W1604663875 hasConcept C2777521759 @default.
• W1604663875 hasConcept C2778540859 @default.
• W1604663875 hasConcept C2779587474 @default.
• W1604663875 hasConcept C42360764 @default.
• W1604663875 hasConcept C43617362 @default.
• W1604663875 hasConcept C54400483 @default.
• W1604663875 hasConcept C71924100 @default.
• W1604663875 hasConcept C88380143 @default.
• W1604663875 hasConcept C98274493 @default.
• W1604663875 hasConceptScore W1604663875C10138342 @default.
• W1604663875 hasConceptScore W1604663875C127172972 @default.
• W1604663875 hasConceptScore W1604663875C127413603 @default.
• W1604663875 hasConceptScore W1604663875C155574463 @default.
• W1604663875 hasConceptScore W1604663875C159985019 @default.
• W1604663875 hasConceptScore W1604663875C162324750 @default.
• W1604663875 hasConceptScore W1604663875C178790620 @default.
• W1604663875 hasConceptScore W1604663875C181389837 @default.
• W1604663875 hasConceptScore W1604663875C185592680 @default.
• W1604663875 hasConceptScore W1604663875C187530423 @default.
• W1604663875 hasConceptScore W1604663875C192562407 @default.
• W1604663875 hasConceptScore W1604663875C2776964284 @default.
• W1604663875 hasConceptScore W1604663875C2777521759 @default.
• W1604663875 hasConceptScore W1604663875C2778540859 @default.
• W1604663875 hasConceptScore W1604663875C2779587474 @default.
• W1604663875 hasConceptScore W1604663875C42360764 @default.
• W1604663875 hasConceptScore W1604663875C43617362 @default.
• W1604663875 hasConceptScore W1604663875C54400483 @default.
• W1604663875 hasConceptScore W1604663875C71924100 @default.
• W1604663875 hasConceptScore W1604663875C88380143 @default.
• W1604663875 hasConceptScore W1604663875C98274493 @default.
• W1604663875 hasIssue "3" @default.
• W1604663875 hasLocation W16046638751 @default.
• W1604663875 hasLocation W16046638752 @default.
• W1604663875 hasOpenAccess W1604663875 @default.
• W1604663875 hasPrimaryLocation W16046638751 @default.
• W1604663875 hasRelatedWork W1520863526 @default.

• next