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- W160497099 abstract "Objective: To report our experience with lamotrigine(LTG)-related skin rash in children with epilepsy.Methods: We identified a series of consecutive childrenwith epilepsy treated with LTG prospectively over a 5-year period ending 1st October 2005 at King Abdul-AzizUniversity Hospital and King Faisal Specialist Hospitaland Research Center, Jeddah, Kingdom of SaudiArabia.Results: Of 207 children on LTG, 15 (7.2%) developeda skin rash with ages ranging between 3-12 years (mean7.5). We used LTG as monotherapy in 3/15 and as addon in 12/15, mostly (10/15) in addition to valproic acid(VPA). The rash was mild with complete recovery in 7children (47%). The remaining 8 (3.9% of the total)had severe rash that necessitated admission to hospital.Seven out of these 8 children were also receiving VPA.One child had superimposed secondary bacterialinfection and admitted for intravenous antibiotics.Two children recovered slowly with extensive postinflammatoryhyperpigmentation. We diagnosedStevens-Johnson syndrome in 5 children (2.4% of thetotal). One of these 5 children had progressive symptomsthat evolved to toxic epidermal necrolysis. He requiredprolonged intensive care admission and developedsepsis with disseminated intravascular coagulopathy.He deteriorated despite supportive therapy, and died 5weeks after the initiation of LTG therapy.Conclusions: Lamotrigine is a novel antiepileptic drugwith a favorable therapeutic profile and good tolerability.However, LTG-related skin rash is a potentially seriousadverse event that should be carefully monitored.Although the risk is small, one should weigh this againstthe potential benefits, particularly in children on VPA" @default.
- W160497099 created "2016-06-24" @default.
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- W160497099 date "2007-01-01" @default.
- W160497099 modified "2023-09-28" @default.
- W160497099 title "Potentially serious Lamotrigine-related skin rash" @default.
- W160497099 hasPublicationYear "2007" @default.
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