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- W1605065321 abstract "Mice were treated with increasing doses of morphine for 6 weeks and changes in brain acetylcholine (ACh) metabolism were investigated. The administration of a single dose of morphine (100 mg kg ) caused a marked increase in brain ACh content in normal animals, but this increase was not found in animals that had received chronic administration of morphine. Morphine did not affect the activity of cholinesterase (ChE) in vivo , and no significant difference was observed between the brain ChE activity of normal and morphinized animals. These results indicate that ACh metabolism in brain may be involved in the mechanism of the development of tolerance to morphine." @default.
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- W1605065321 date "1964-03-01" @default.
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- W1605065321 title "Pharmacological studies of analgesics—VI" @default.
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- W1605065321 doi "https://doi.org/10.1016/0006-2952(64)90164-9" @default.
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