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- W1605094018 abstract "271 Objectives: This study was performed to validate the efficacy of FLT-positron emission tomography (PET) as a noninvasive tumor proliferation imaging method and the safety of FLT as a diagnostic radiopharmaceutical. Methods: A prospective, nonrandomized, phase III clinical trial was performed in a single center. Adult (>18 yr) patient(pt)s with primary lung cancer with > 1.5 cm in size, scheduled to surgery after staging work-up were eligible. Before surgery, FLT-PET images of chest field were obtained using a PET/CT scanner at 1 hr after injection of 370 MBq FLT. Standardized uptake values (SUV) of tumor were measured using a threshold (80% of maxSUV) defined volume of interest. After surgery, Ki-67 values of tumor were measured by two pathologists who were blind to FLT-PET results. The primary endpoint of this study was a good correlation between the measurements of tumor proliferation by SUVs using FLT-PET and Ki-67 values (H0; ρ ≤ 0.5 vs H0; ρ > 0.5, p 0.05) in tumors > 3 cm in size. In all 110 pts, 10 mild or moderate adverse reactions were recorded, but no reaction was considered to be related to FLT and all pts recovered. Conclusions: FLT-PET is an effective and safe imaging method to measure tumor proliferation in vivo." @default.
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- W1605094018 date "2007-05-01" @default.
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- W1605094018 title "A phase III clinical trial to evaluate the measurement of tumor proliferation using [18F]Fluoro-3’-deoxy-3’-L-fluorothymidine (FLT) positron emission tomography in patients with lung cancer" @default.
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