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• W1605113209 abstract "Background and Purpose N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasma increases when diets rich in fish or krill oil are consumed. DHEA displays anti-inflammatory properties in vitro and was found to be released during an inflammatory response in mice. Here, we further examine possible targets involved in the immune-modulating effects of DHEA. Experimental Approach Antagonists for cannabinoid (CB)1 and CB2 receptors and PPARγ were used to explore effects of DHEA on NO release by LPS-stimulated RAW264.7 cells. The possible involvement of CB2 receptors was studied by comparing effects in LPS-stimulated peritoneal macrophages obtained from CB2−/− and CB2+/+ mice. Effects on NF-κB activation were determined using a reporter cell line. To study DHEA effects on COX-2 and lipoxygenase activity, 21 different eicosanoids produced by LPS-stimulated RAW264.7 cells were quantified by LC-MS/MS. Finally, effects on mRNA expression profiles were analysed using gene arrays followed by Ingenuity® Pathways Analysis. Key Results CB1 and CB2 receptors or PPARs were not involved in the effects of DHEA on NO release. NF-κB and IFN-β, key elements of the myeloid differentiation primary response protein D88 (MyD88)-dependent and MyD88-independent pathways were not decreased. By contrast, DHEA significantly reduced levels of several COX-2-derived eicosanoids. Gene expression analysis provided support for an effect on COX–2-mediated pathways. Conclusions and Implications Our findings suggest that the anti-inflammatory effects of DHEA in macrophages predominantly take place via inhibition of eicosanoids produced through COX-2. Linked Articles This article is part of a themed section on Cannabinoids 2013 published in volume 171 issue 6. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.2014.171.issue-6/issuetoc" @default.
• W1605113209 created "2016-06-24" @default.
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• W1605113209 date "2014-09-23" @default.
• W1605113209 modified "2023-10-18" @default.
• W1605113209 title "Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid<i>N</i><i>-</i>docosahexaenoylethanolamine (DHEA) in macrophages" @default.
• W1605113209 cites W1484825310 @default.
• W1605113209 cites W1521347253 @default.
• W1605113209 cites W1529023379 @default.
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• W1605113209 cites W1561713829 @default.
• W1605113209 cites W1593555249 @default.
• W1605113209 cites W1596389679 @default.
• W1605113209 cites W1668468546 @default.
• W1605113209 cites W1801222608 @default.
• W1605113209 cites W1916800927 @default.
• W1605113209 cites W1963614756 @default.
• W1605113209 cites W1966725691 @default.
• W1605113209 cites W1975161769 @default.
• W1605113209 cites W1976359846 @default.
• W1605113209 cites W1984769120 @default.
• W1605113209 cites W1989454487 @default.
• W1605113209 cites W1990144502 @default.
• W1605113209 cites W1990802251 @default.
• W1605113209 cites W1990898742 @default.
• W1605113209 cites W1998587775 @default.
• W1605113209 cites W2003156139 @default.
• W1605113209 cites W2004465286 @default.
• W1605113209 cites W2006605504 @default.
• W1605113209 cites W2009922820 @default.
• W1605113209 cites W2010474996 @default.
• W1605113209 cites W2022077377 @default.
• W1605113209 cites W2023632053 @default.
• W1605113209 cites W2035088045 @default.
• W1605113209 cites W2040456660 @default.
• W1605113209 cites W2044168079 @default.
• W1605113209 cites W2047244415 @default.
• W1605113209 cites W2051154935 @default.
• W1605113209 cites W2053461680 @default.
• W1605113209 cites W2055211034 @default.
• W1605113209 cites W2056943042 @default.
• W1605113209 cites W2063837435 @default.
• W1605113209 cites W2069004874 @default.
• W1605113209 cites W2079860184 @default.
• W1605113209 cites W2107104127 @default.
• W1605113209 cites W2109491705 @default.
• W1605113209 cites W2111775116 @default.
• W1605113209 cites W2112755850 @default.
• W1605113209 cites W2119417389 @default.
• W1605113209 cites W2123333711 @default.
• W1605113209 cites W2131094572 @default.
• W1605113209 cites W2131133480 @default.
• W1605113209 cites W2132365435 @default.
• W1605113209 cites W2142488420 @default.
• W1605113209 cites W2143425403 @default.
• W1605113209 cites W2148516429 @default.
• W1605113209 cites W2152571985 @default.
• W1605113209 cites W2155281971 @default.
• W1605113209 cites W2165272223 @default.
• W1605113209 cites W2170019106 @default.
• W1605113209 cites W2170187479 @default.
• W1605113209 cites W2170842129 @default.
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• W1605113209 doi "https://doi.org/10.1111/bph.12747" @default.
• W1605113209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4280965" @default.
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