Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605241954> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1605241954 endingPage "13761" @default.
- W1605241954 startingPage "13758" @default.
- W1605241954 abstract "Infusion of heat-aggregated immunoglobulin G (IgG) into perfused livers from fed rats resulted in a dose-dependent but transient stimulation of hepatic glucose output. Oxygen consumption and lactate production by the liver also were stimulated, while the lactate/pyruvate ratio of the effluent perfusate was increased. Upon return of hepatic glucose output to the basal rate following immune aggregate stimulation, a second infusion of immune aggregate caused little or no increase in glucose output, indicating desensitization of the response. Infusion of immune aggregate into rat livers also resulted in the appearance of platelet-activating factor activity in the effluent perfusate. Synthetic platelet-activating factor or acetylglyceryl ether phosphorylcholine (AGEPC) has been demonstrated to be a potent glycogenolytic agonist in the perfused liver (Buxton, D.B., Shukla, S. D., Hanahan, D. J., and Olson, M.S. (1984) J. Biol. Chem. 259, 1468-1471). The glycogenolytic response of the liver to immune aggregate infusion was not desensitized by prior infusion of AGEPC. Co-infusion of the cyclooxygenase inhibitor indomethacin prevented the immune aggregate-induced glycogenolytic response but had no effect on AGEPC-stimulated hepatic glucose output. It is suggested that the mechanism by which aggregated IgG activates hepatic glycogenolysis requires the synthesis of AGEPC by the liver by a pathway which involves the metabolism of arachadonic acid." @default.
- W1605241954 created "2016-06-24" @default.
- W1605241954 creator A5002243330 @default.
- W1605241954 creator A5040333264 @default.
- W1605241954 creator A5056416573 @default.
- W1605241954 date "1984-11-01" @default.
- W1605241954 modified "2023-10-18" @default.
- W1605241954 title "Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobulin G in the perfused rat liver." @default.
- W1605241954 cites W1480967651 @default.
- W1605241954 cites W1502847806 @default.
- W1605241954 cites W1508779133 @default.
- W1605241954 cites W1514833272 @default.
- W1605241954 cites W1517662067 @default.
- W1605241954 cites W1517766790 @default.
- W1605241954 cites W1542584079 @default.
- W1605241954 cites W1593453854 @default.
- W1605241954 cites W1893528652 @default.
- W1605241954 cites W1972935892 @default.
- W1605241954 cites W1984422384 @default.
- W1605241954 cites W2075889998 @default.
- W1605241954 cites W2076072336 @default.
- W1605241954 cites W2093541003 @default.
- W1605241954 cites W2123401079 @default.
- W1605241954 cites W2124264312 @default.
- W1605241954 cites W2129399556 @default.
- W1605241954 cites W2166376385 @default.
- W1605241954 cites W2300552860 @default.
- W1605241954 cites W2316431777 @default.
- W1605241954 cites W2329082982 @default.
- W1605241954 cites W2432195370 @default.
- W1605241954 cites W4313309210 @default.
- W1605241954 doi "https://doi.org/10.1016/s0021-9258(18)89810-6" @default.
- W1605241954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6501277" @default.
- W1605241954 hasPublicationYear "1984" @default.
- W1605241954 type Work @default.
- W1605241954 sameAs 1605241954 @default.
- W1605241954 citedByCount "56" @default.
- W1605241954 countsByYear W16052419542021 @default.
- W1605241954 crossrefType "journal-article" @default.
- W1605241954 hasAuthorship W1605241954A5002243330 @default.
- W1605241954 hasAuthorship W1605241954A5040333264 @default.
- W1605241954 hasAuthorship W1605241954A5056416573 @default.
- W1605241954 hasBestOaLocation W16052419541 @default.
- W1605241954 hasConcept C126322002 @default.
- W1605241954 hasConcept C134018914 @default.
- W1605241954 hasConcept C159654299 @default.
- W1605241954 hasConcept C185592680 @default.
- W1605241954 hasConcept C203014093 @default.
- W1605241954 hasConcept C24998067 @default.
- W1605241954 hasConcept C2777499176 @default.
- W1605241954 hasConcept C2777949327 @default.
- W1605241954 hasConcept C71924100 @default.
- W1605241954 hasConcept C86803240 @default.
- W1605241954 hasConcept C89560881 @default.
- W1605241954 hasConceptScore W1605241954C126322002 @default.
- W1605241954 hasConceptScore W1605241954C134018914 @default.
- W1605241954 hasConceptScore W1605241954C159654299 @default.
- W1605241954 hasConceptScore W1605241954C185592680 @default.
- W1605241954 hasConceptScore W1605241954C203014093 @default.
- W1605241954 hasConceptScore W1605241954C24998067 @default.
- W1605241954 hasConceptScore W1605241954C2777499176 @default.
- W1605241954 hasConceptScore W1605241954C2777949327 @default.
- W1605241954 hasConceptScore W1605241954C71924100 @default.
- W1605241954 hasConceptScore W1605241954C86803240 @default.
- W1605241954 hasConceptScore W1605241954C89560881 @default.
- W1605241954 hasIssue "22" @default.
- W1605241954 hasLocation W16052419541 @default.
- W1605241954 hasOpenAccess W1605241954 @default.
- W1605241954 hasPrimaryLocation W16052419541 @default.
- W1605241954 hasRelatedWork W2017653266 @default.
- W1605241954 hasRelatedWork W2020551231 @default.
- W1605241954 hasRelatedWork W2022869754 @default.
- W1605241954 hasRelatedWork W2044049094 @default.
- W1605241954 hasRelatedWork W2110281844 @default.
- W1605241954 hasRelatedWork W2299293856 @default.
- W1605241954 hasRelatedWork W2411392087 @default.
- W1605241954 hasRelatedWork W2461558938 @default.
- W1605241954 hasRelatedWork W2748952813 @default.
- W1605241954 hasRelatedWork W4235769950 @default.
- W1605241954 hasVolume "259" @default.
- W1605241954 isParatext "false" @default.
- W1605241954 isRetracted "false" @default.
- W1605241954 magId "1605241954" @default.
- W1605241954 workType "article" @default.