Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605292634> ?p ?o ?g. }
- W1605292634 endingPage "76" @default.
- W1605292634 startingPage "71" @default.
- W1605292634 abstract "Thrombin is a serine protease that cleaves the peptide bonds in proteins located on the carboxyl side of arginine. Thrombin plays a central role in thromboembolic diseases, which are the major cause of mortality. The aim of the study was to estimate the effects of plant extracts on proteolytic properties of thrombin. Thrombin was incubated with polyphenol‐rich extracts from berries of Aronia melanocarpa or seeds of Vitis vinifera (0.5, 5, 50 µg/mL) and with polyphenols ((+)‐catechin, (−)‐epicatechin, gallic acid, chlorogenic acid, procyanidin B1, cyanidin, cyanidin 3‐glucoside, quercetin). The in vitro experiments showed that both extracts in all used concentrations inhibited proteolytic activity of thrombin observed as inhibition of thrombin‐induced fibrinogen polymerization, stabilized fibrin formation, and platelet aggregation. Moreover, thrombin amidolytic activity was inhibited by polyphenols belonging to the flavonoid class. Results presented in this study indicate that polyphenol‐rich extracts from berries of A. melanocarpa and seeds of V. vinifera may become promising dietary supplements in the prevention of thrombotic states. Copyright © 2012 John Wiley & Sons, Ltd." @default.
- W1605292634 created "2016-06-24" @default.
- W1605292634 creator A5012292529 @default.
- W1605292634 creator A5033678080 @default.
- W1605292634 creator A5057816133 @default.
- W1605292634 creator A5060187731 @default.
- W1605292634 date "2012-04-04" @default.
- W1605292634 modified "2023-10-18" @default.
- W1605292634 title "Antithrombin Effect of Polyphenol-Rich Extracts from Black Chokeberry and Grape Seeds" @default.
- W1605292634 cites W1520965512 @default.
- W1605292634 cites W1546487882 @default.
- W1605292634 cites W1889671843 @default.
- W1605292634 cites W1914622032 @default.
- W1605292634 cites W1932972513 @default.
- W1605292634 cites W194688329 @default.
- W1605292634 cites W1958081034 @default.
- W1605292634 cites W1963923094 @default.
- W1605292634 cites W1963938486 @default.
- W1605292634 cites W1967889750 @default.
- W1605292634 cites W1970201989 @default.
- W1605292634 cites W1972959684 @default.
- W1605292634 cites W1973907400 @default.
- W1605292634 cites W1975398550 @default.
- W1605292634 cites W1978294735 @default.
- W1605292634 cites W1999106335 @default.
- W1605292634 cites W2002575319 @default.
- W1605292634 cites W2018007254 @default.
- W1605292634 cites W2024187469 @default.
- W1605292634 cites W2029453461 @default.
- W1605292634 cites W2035430953 @default.
- W1605292634 cites W2036635819 @default.
- W1605292634 cites W2045062807 @default.
- W1605292634 cites W2047107857 @default.
- W1605292634 cites W2047492665 @default.
- W1605292634 cites W2052687467 @default.
- W1605292634 cites W2056279056 @default.
- W1605292634 cites W2059581409 @default.
- W1605292634 cites W2061922506 @default.
- W1605292634 cites W2070563445 @default.
- W1605292634 cites W2078132464 @default.
- W1605292634 cites W2101296091 @default.
- W1605292634 cites W2118236312 @default.
- W1605292634 cites W2119331100 @default.
- W1605292634 cites W2136489990 @default.
- W1605292634 cites W2145350289 @default.
- W1605292634 cites W2154400398 @default.
- W1605292634 cites W2160439330 @default.
- W1605292634 cites W4210663131 @default.
- W1605292634 cites W4211160326 @default.
- W1605292634 cites W4234966965 @default.
- W1605292634 cites W4250468389 @default.
- W1605292634 cites W530199 @default.
- W1605292634 doi "https://doi.org/10.1002/ptr.4682" @default.
- W1605292634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22473647" @default.
- W1605292634 hasPublicationYear "2012" @default.
- W1605292634 type Work @default.
- W1605292634 sameAs 1605292634 @default.
- W1605292634 citedByCount "32" @default.
- W1605292634 countsByYear W16052926342013 @default.
- W1605292634 countsByYear W16052926342014 @default.
- W1605292634 countsByYear W16052926342015 @default.
- W1605292634 countsByYear W16052926342016 @default.
- W1605292634 countsByYear W16052926342017 @default.
- W1605292634 countsByYear W16052926342018 @default.
- W1605292634 countsByYear W16052926342019 @default.
- W1605292634 countsByYear W16052926342020 @default.
- W1605292634 countsByYear W16052926342021 @default.
- W1605292634 countsByYear W16052926342023 @default.
- W1605292634 crossrefType "journal-article" @default.
- W1605292634 hasAuthorship W1605292634A5012292529 @default.
- W1605292634 hasAuthorship W1605292634A5033678080 @default.
- W1605292634 hasAuthorship W1605292634A5057816133 @default.
- W1605292634 hasAuthorship W1605292634A5060187731 @default.
- W1605292634 hasConcept C185592680 @default.
- W1605292634 hasConcept C203014093 @default.
- W1605292634 hasConcept C2777292125 @default.
- W1605292634 hasConcept C2778004101 @default.
- W1605292634 hasConcept C2778362808 @default.
- W1605292634 hasConcept C2779431889 @default.
- W1605292634 hasConcept C2780117898 @default.
- W1605292634 hasConcept C31903555 @default.
- W1605292634 hasConcept C55493867 @default.
- W1605292634 hasConcept C70899900 @default.
- W1605292634 hasConcept C86803240 @default.
- W1605292634 hasConcept C89560881 @default.
- W1605292634 hasConceptScore W1605292634C185592680 @default.
- W1605292634 hasConceptScore W1605292634C203014093 @default.
- W1605292634 hasConceptScore W1605292634C2777292125 @default.
- W1605292634 hasConceptScore W1605292634C2778004101 @default.
- W1605292634 hasConceptScore W1605292634C2778362808 @default.
- W1605292634 hasConceptScore W1605292634C2779431889 @default.
- W1605292634 hasConceptScore W1605292634C2780117898 @default.
- W1605292634 hasConceptScore W1605292634C31903555 @default.
- W1605292634 hasConceptScore W1605292634C55493867 @default.
- W1605292634 hasConceptScore W1605292634C70899900 @default.
- W1605292634 hasConceptScore W1605292634C86803240 @default.
- W1605292634 hasConceptScore W1605292634C89560881 @default.
- W1605292634 hasIssue "1" @default.