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• W1605373213 abstract "Alterations in sensory experience can persistently modify the responses of cortical neurons. Ocular dominance (OD) plasticity, a process in which alternation of visual input induces a shift in cortical responsiveness, is an extensively studied model of such experience-dependent plasticity. However, the synaptic mechanisms underlying OD plasticity are not well understood. Recent studies revealed that both Hebbian and homeostatic mechanisms play a role in OD plasticity. Therefore, we were interested in monitoring the process of rapid plasticity at individual synapses in vivo to gain insight into the interplay of these two mechanisms. Ca/calmodulin dependent protein kinase II (CaMKII) is a major component of the postsynaptic density. Activation of CaMKII is necessary and sufficient for LTP induction, is required for OD plasticity, and its expression pattern coincides with the site of rapid plasticity in the supragranular layers II/III of the visual cortex. Moreover, CaMKII can convert transient Ca influx into a prolonged biochemical process via autophosphorylation that renders CaMKII activity Ca independent. Hence, CaMKII is well suited as a reporter of synaptic activity. We previously engineered a probe, Camui, which utilizes the optical phenomenon of fluorescence resonance energy transfer (FRET), to monitor CaMKII activation. This thesis embodies the work done to improve Camui to be a better tool for in vivo reporting of CaMKII activity, as well as the use of this improved probe for in vivo detection of CaMKIIα activity in single spines before and after 4 hrs of monocular deprivation (MD) in the ferret visual cortex. We found that after only 4 hrs of MD, the overall CaMKIIα activity in spines, and adjacent dendritic regions, of neurons in the deprived eye domain increased significantly. This increase was also seen in the binocular eye domain. In the open eye domain, however, this overall increase in CaMKIIα activity was absent. These observations were specific to MD as control experiments did not show such changes. Moreover, detailed analysis revealed that spines that were eliminated after 4 hrs of MD had a low level of basal CaMKIIα activity. Our results lend support to the model that both Hebbian, as well as homeostatic compensatory mechanism can subserve OD plasticity. Thesis Supervisor: Yasunori Hayashi, M.D., Ph.D. Title: Assistant Professor of Neurobiology" @default.
• W1605373213 created "2016-06-24" @default.
• W1605373213 creator A5074877440 @default.
• W1605373213 date "2009-01-01" @default.
• W1605373213 modified "2023-09-26" @default.
• W1605373213 title "In vivo visualization of CaMKII activity in ocular dominance plasticity" @default.
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