Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605441402> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1605441402 endingPage "3548" @default.
- W1605441402 startingPage "3544" @default.
- W1605441402 abstract "AIM: To verify whether P-glycoprotein (P-gp) could induce cell resistance to apoptosis by inhibiting caspase-8 and caspase-3.METHODS: Human KB cells, either drug-sensitive or with multidrug resistance (MDR) phenotype caused by overexpression of P-gp (KBv200 cells), were treated with anti-Fas (CH-11 monoclonal antibody) to induce apoptosis.Cytotoxicity was detected by MTT assay. Symptoms of cell death were assessed by morphological observation after Hoechst33258 staining, activation of caspase-8 and caspase-3 was measured by Western blotting.RESULTS: Compared with KB cells, the resistance of KBv200 cells to VCR (vincristine) was about 51-fold higher.Anti-Fas (CH-11) induced cytotoxicity and apoptosis in both sensitive KB cells and MDR phenotype KBv200cells. The IC50 of CH-11 in KB cells was similar to that in KBv200 cells. CH-11 induced similar apoptotic rates in both KB cells and KBv200 cells, which could be classified as caspase-dependent apoptotic pathway. Verapamil (VRP) did not affect CH-11-mediated apoptosis in KBv200 cells.CONCLUSION: Expression of P-glycoprotein does not induce resistance to caspase-8 and -3 activation or antiFas-induced cell apoptosis." @default.
- W1605441402 created "2016-06-24" @default.
- W1605441402 creator A5005610501 @default.
- W1605441402 creator A5024687080 @default.
- W1605441402 creator A5028865651 @default.
- W1605441402 creator A5030523606 @default.
- W1605441402 creator A5033731931 @default.
- W1605441402 creator A5041740284 @default.
- W1605441402 date "2005-01-01" @default.
- W1605441402 modified "2023-09-23" @default.
- W1605441402 title "P-glycoprotein is not involved in pathway of anti-Fas／Fas-induced apoptosis in KBv200 cells" @default.
- W1605441402 hasPublicationYear "2005" @default.
- W1605441402 type Work @default.
- W1605441402 sameAs 1605441402 @default.
- W1605441402 citedByCount "0" @default.
- W1605441402 crossrefType "journal-article" @default.
- W1605441402 hasAuthorship W1605441402A5005610501 @default.
- W1605441402 hasAuthorship W1605441402A5024687080 @default.
- W1605441402 hasAuthorship W1605441402A5028865651 @default.
- W1605441402 hasAuthorship W1605441402A5030523606 @default.
- W1605441402 hasAuthorship W1605441402A5033731931 @default.
- W1605441402 hasAuthorship W1605441402A5041740284 @default.
- W1605441402 hasConcept C109316439 @default.
- W1605441402 hasConcept C133936738 @default.
- W1605441402 hasConcept C153911025 @default.
- W1605441402 hasConcept C154317977 @default.
- W1605441402 hasConcept C185592680 @default.
- W1605441402 hasConcept C190283241 @default.
- W1605441402 hasConcept C202751555 @default.
- W1605441402 hasConcept C2778707650 @default.
- W1605441402 hasConcept C2780783641 @default.
- W1605441402 hasConcept C31573885 @default.
- W1605441402 hasConcept C48297814 @default.
- W1605441402 hasConcept C501593827 @default.
- W1605441402 hasConcept C54355233 @default.
- W1605441402 hasConcept C55493867 @default.
- W1605441402 hasConcept C81885089 @default.
- W1605441402 hasConcept C86803240 @default.
- W1605441402 hasConcept C95444343 @default.
- W1605441402 hasConcept C98424977 @default.
- W1605441402 hasConceptScore W1605441402C109316439 @default.
- W1605441402 hasConceptScore W1605441402C133936738 @default.
- W1605441402 hasConceptScore W1605441402C153911025 @default.
- W1605441402 hasConceptScore W1605441402C154317977 @default.
- W1605441402 hasConceptScore W1605441402C185592680 @default.
- W1605441402 hasConceptScore W1605441402C190283241 @default.
- W1605441402 hasConceptScore W1605441402C202751555 @default.
- W1605441402 hasConceptScore W1605441402C2778707650 @default.
- W1605441402 hasConceptScore W1605441402C2780783641 @default.
- W1605441402 hasConceptScore W1605441402C31573885 @default.
- W1605441402 hasConceptScore W1605441402C48297814 @default.
- W1605441402 hasConceptScore W1605441402C501593827 @default.
- W1605441402 hasConceptScore W1605441402C54355233 @default.
- W1605441402 hasConceptScore W1605441402C55493867 @default.
- W1605441402 hasConceptScore W1605441402C81885089 @default.
- W1605441402 hasConceptScore W1605441402C86803240 @default.
- W1605441402 hasConceptScore W1605441402C95444343 @default.
- W1605441402 hasConceptScore W1605441402C98424977 @default.
- W1605441402 hasIssue "23" @default.
- W1605441402 hasLocation W16054414021 @default.
- W1605441402 hasOpenAccess W1605441402 @default.
- W1605441402 hasPrimaryLocation W16054414021 @default.
- W1605441402 hasRelatedWork W1673314361 @default.
- W1605441402 hasRelatedWork W1964357828 @default.
- W1605441402 hasRelatedWork W1990059081 @default.
- W1605441402 hasRelatedWork W2002911984 @default.
- W1605441402 hasRelatedWork W2019299363 @default.
- W1605441402 hasRelatedWork W2028934024 @default.
- W1605441402 hasRelatedWork W2029984735 @default.
- W1605441402 hasRelatedWork W2033030472 @default.
- W1605441402 hasRelatedWork W2058618472 @default.
- W1605441402 hasRelatedWork W2072119241 @default.
- W1605441402 hasRelatedWork W2093961965 @default.
- W1605441402 hasRelatedWork W2169280597 @default.
- W1605441402 hasRelatedWork W2262719757 @default.
- W1605441402 hasRelatedWork W2314659450 @default.
- W1605441402 hasRelatedWork W2315433380 @default.
- W1605441402 hasRelatedWork W2317335867 @default.
- W1605441402 hasRelatedWork W2322612164 @default.
- W1605441402 hasRelatedWork W2375039259 @default.
- W1605441402 hasRelatedWork W3093071097 @default.
- W1605441402 hasRelatedWork W2474291412 @default.
- W1605441402 hasVolume "11" @default.
- W1605441402 isParatext "false" @default.
- W1605441402 isRetracted "false" @default.
- W1605441402 magId "1605441402" @default.
- W1605441402 workType "article" @default.