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- W1605454236 abstract "This chapter discusses the anatomy, physiology, and pharmacology of the periaqueductal gray (PAG) contribution to antinociceptive controls. Studies emphasized the multiplicity of the bulbospinal antinociceptive control systems that are activated by electrical stimulation of or microinjection of opiates into the midbrain PAG. There are important noradrenergic controls and a wide variety of peptide-containing bulbospinal neurons. The chapter summarizes the cytochemistry of the afferent and efferent connections of the PAG and some intrinsic circuits within the PAG through which the controls are activated. The complexity of antinociceptive controls exerted from the midbrain PAG is illustrated. Anatomically and functionally, the PAG is heterogeneous. There is evidence that β-endorphin, enkephalin, dynorphin, gamma-aminobutyric acid (GABA), and neurotensin neurons contribute to the controls generated from the PAG. Electrical stimulation of or microinjection of drugs into the PAG activates multiple stages of this circuitry. The complex interaction of narcotics, such as morphine, with the multiple opioid receptor sites in the PAG makes interpretation of drug injection studies equally complicated." @default.
- W1605454236 created "2016-06-24" @default.
- W1605454236 creator A5007740596 @default.
- W1605454236 creator A5013173664 @default.
- W1605454236 creator A5066418974 @default.
- W1605454236 date "1988-01-01" @default.
- W1605454236 modified "2023-10-03" @default.
- W1605454236 title "Chapter 2 Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls" @default.
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- W1605454236 doi "https://doi.org/10.1016/s0079-6123(08)62777-6" @default.
- W1605454236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3064173" @default.