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• W1605514044 abstract "Sidha medicines which are popular in Southern parts of India have significant quantity of heavy metals. It is claimed that mode of preparation of these drugs reduces their toxicities. However toxicity studies of Sidha preparations are seldom carried out. In the present study we have evaluated toxicity of Rasagandhi Mezhugu (RM), a Sidha preparation in Wistar rats. Drug was administered orally as single dose (acute) and sixty doses (chronic). Parameters checked were WBC count, haemoglobin and differential count, hepatic function tests such as SGOT, SGPT, ALP, bilirubin, creatinine, blood urea nitrogen, total protein, albumin, globulin and renal function tests such as blood urea nitrogen and creatinine, electrolytes such as sodium, potassium, bicarbonate and chloride. No impairment in hepatic, renal, haemopoietic functions were observed throughout the study. Histopathological analysis revealed that liver, kidney, spleen and thymus tissues of treated groups did not show any signs of toxicity. However, astrocytes showed mild hyperplasia, stroma showed oedema in the treated group. Cerebellum also shows stromal oedema. Rasagandhi Mezhugu (RM) administration for one year to HIV patients did not produce any toxicity as seen from liver function and renal function as well as analyzing haematological parameters. Analysis of the metal content in the tissues of RGM treated rats for one month indicated that there was significant accumulation of mercury and copper in the tissues, which indicate that RGM administration for long period of times can produce heavy metal toxicity which is also indicated in histopathological analysis. Sidha medicine is being practiced in Southern part of India. Most medical practitioners caution against using Sidha medicines due to the extensive use of heavy metals like lead and mercury in the preparation. Drugs having these heavy metals more than their allowable limits are banned in many countries. Sidha practitioners claim that the heavy metals used in these medicines are completely transformed into inert compounds or ores through a 18-step process before being prescribed as medicine. However extensive research is necessary to solve such riddles of the transformation of these admittedly poisonous compounds. Recently Sidha system of medicare has been found to have useful in the management of HIV through scientific research involving viral load assays and CD4 + /CD8 + ratios (1). Rasagandhi Mezhugu (RGM) in the form of a capsule is being used for the treatment of HIV by some practitioners (2). This preparation contain 38 different botanicals, many of which have been shown to possess therapeutic efficacy, and 8 inorganic compounds such as mercury, sulphur, calomel (mercury chloride), yellow orpiment (arsenic sulphide), lodestone (iron), blue vitriol (copper sulfate), calamine (zinc oxide) and litharge (lead oxide), all prepared into a paste in palm sugar and hen's egg base. Composition of RGM is given elsewhere (3)." @default.
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• W1605514044 date "2010-08-11" @default.
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• W1605514044 title "Toxicity Studies of Sidha Medicine - Rasagandhi Mezhugu" @default.
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