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- W1605590717 abstract "The motor symptoms of Parkinson's disease (PD) are primarily due to the degeneration of the dopaminergic neurons in the nigrostriatal pathway. However, several other brain areas and neurotransmitters other than dopamine such as noradrenaline, 5-hydroxytryptamine and acetylcholine are affected in the disease. Moreover, adenosine because of the extensive interaction of its receptors with the dopaminergic system has been implicated in the pathophysiology of the disease. Based on the involvement of these non-dopaminergic neurotransmitters in PD and the sometimes severe adverse effects that limit the mainstay use of dopamine-based anti-parkinsonian treatments, recent assessments have called for a broadening of therapeutic options beyond the traditional dopaminergic drug arsenal. In this review we describe the interactions between dopamine and adenosine receptors that underpin the pre-clinical and clinical rationale for pursuing adenosine A(2A) receptor antagonists as symptomatic and potentially neuroprotective treatment of PD. The review will pay particular attention to recent results regarding specific A(2A) receptor-receptor interactions and recent findings identifying urate, the end product of purine metabolism, as a novel prognostic biomarker and candidate neuroprotectant in PD." @default.
- W1605590717 created "2016-06-24" @default.
- W1605590717 creator A5037805233 @default.
- W1605590717 creator A5041777746 @default.
- W1605590717 creator A5047999265 @default.
- W1605590717 creator A5060217553 @default.
- W1605590717 date "2010-01-01" @default.
- W1605590717 modified "2023-10-12" @default.
- W1605590717 title "Pathophysiological roles for purines" @default.
- W1605590717 cites W1507839329 @default.
- W1605590717 cites W1576503935 @default.
- W1605590717 cites W1592905469 @default.
- W1605590717 cites W1602198998 @default.
- W1605590717 cites W1670130194 @default.
- W1605590717 cites W1832537945 @default.
- W1605590717 cites W1844553425 @default.
- W1605590717 cites W1965280907 @default.
- W1605590717 cites W1965352385 @default.
- W1605590717 cites W1967630657 @default.
- W1605590717 cites W1968906899 @default.
- W1605590717 cites W1972288745 @default.
- W1605590717 cites W1974463013 @default.
- W1605590717 cites W1974588747 @default.
- W1605590717 cites W1977197484 @default.
- W1605590717 cites W1978647688 @default.
- W1605590717 cites W1979095213 @default.
- W1605590717 cites W1980659372 @default.
- W1605590717 cites W1981724976 @default.
- W1605590717 cites W1982560563 @default.
- W1605590717 cites W1982734210 @default.
- W1605590717 cites W1983415204 @default.
- W1605590717 cites W1985419794 @default.
- W1605590717 cites W1986317942 @default.
- W1605590717 cites W1986669328 @default.
- W1605590717 cites W1987380827 @default.
- W1605590717 cites W1988453521 @default.
- W1605590717 cites W1989639366 @default.
- W1605590717 cites W1990242009 @default.
- W1605590717 cites W1990269363 @default.
- W1605590717 cites W1991046140 @default.
- W1605590717 cites W1993761825 @default.
- W1605590717 cites W1994403848 @default.
- W1605590717 cites W1995287360 @default.
- W1605590717 cites W1996252596 @default.
- W1605590717 cites W1997736051 @default.
- W1605590717 cites W1999869745 @default.
- W1605590717 cites W2000411175 @default.
- W1605590717 cites W2001945015 @default.
- W1605590717 cites W2003483275 @default.
- W1605590717 cites W2003562619 @default.
- W1605590717 cites W2005527892 @default.
- W1605590717 cites W2006115845 @default.
- W1605590717 cites W2008871586 @default.
- W1605590717 cites W2010114986 @default.
- W1605590717 cites W2010405290 @default.
- W1605590717 cites W2012191069 @default.
- W1605590717 cites W2014863293 @default.
- W1605590717 cites W2016675737 @default.
- W1605590717 cites W2017918858 @default.
- W1605590717 cites W2018552952 @default.
- W1605590717 cites W2018826751 @default.
- W1605590717 cites W2019762265 @default.
- W1605590717 cites W2019933893 @default.
- W1605590717 cites W2023504042 @default.
- W1605590717 cites W2024430647 @default.
- W1605590717 cites W2025372788 @default.
- W1605590717 cites W2027389323 @default.
- W1605590717 cites W2027692436 @default.
- W1605590717 cites W2028129201 @default.
- W1605590717 cites W2028285705 @default.
- W1605590717 cites W2028692950 @default.
- W1605590717 cites W2030152049 @default.
- W1605590717 cites W2031806029 @default.
- W1605590717 cites W2032381582 @default.
- W1605590717 cites W2032517939 @default.
- W1605590717 cites W2032605993 @default.
- W1605590717 cites W2032609908 @default.
- W1605590717 cites W2033118995 @default.
- W1605590717 cites W2033442386 @default.
- W1605590717 cites W2035725338 @default.
- W1605590717 cites W2036589433 @default.
- W1605590717 cites W2037199903 @default.
- W1605590717 cites W2037654673 @default.
- W1605590717 cites W2038780437 @default.
- W1605590717 cites W2038822546 @default.
- W1605590717 cites W2039197913 @default.
- W1605590717 cites W2040108360 @default.
- W1605590717 cites W2040253009 @default.
- W1605590717 cites W2041888135 @default.
- W1605590717 cites W2042007142 @default.
- W1605590717 cites W2043885800 @default.
- W1605590717 cites W2044301280 @default.
- W1605590717 cites W2046065660 @default.
- W1605590717 cites W2048365284 @default.
- W1605590717 cites W2049816046 @default.
- W1605590717 cites W2051691242 @default.
- W1605590717 cites W2052791467 @default.
- W1605590717 cites W2056083897 @default.