FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605599114> ?p ?o ?g. }

• W1605599114 abstract "ABSTRACT ANALYSIS OF GABA AND GLUTAMATE IN MICE BRAIN by STELLA WISIDAGAMA May 2011 Advisor: Dr. Tiffany Mathews Major: Chemistry (Analytical) Degree: Master of Science GABA and glutamate are the predominant inhibitory and excitatory amino acid neurotransmitters in the central nervous system (CNS), respectively. However, their altered levels cause several neurological diseases including Parkinson's and Huntington's disease, schizophrenia, and epilepsy. It is important to measure their levels in the extra- and intracellular environments to better understand and develop improved therapeutics that will treat these neurological disorders. The principle aim of this study is to study the impacts of different endogenous and exogenous factors on the striatal extracellular GABA and glutamate levels. The first objective was to develop a method to analyze GABA and glutamate using HPLC coupled to fluorescence detection. The second objective was to evaluate the effects of BDNF, age, ethanol, and Mn exposure on the striatal GABA and glutamate levels. Using a monolithic column, GABA and glutamate were separated in dialysis samples at 2 and 4.5 minutes, respectively. Low levels of endogenous BDNF, acute administration of ethanol (2 g/kg), and age differently affect the GABA and glutamate levels. In BDNF+/- mice potassium stimulated release of glutamate was significantly reduced while release of GABA was not different between wildtype and BDNF+/- mice. Administration of ethanol increased extracellular levels of GABA in both wildtype and BDNF+/- mice. The impact of age on striatal extracellular GABA and glutamate levels was evaluated in mice 3 and 18 months old. Aged mice showed a significant reduction in both high K+-stimulated GABA and glutamate release. The final study evaluated the effect of a sub-acute Mn treatment on striatal extracellular GABA levels, where a modest but significant increase in extracellular GABA was observed 2 days after Mn treatment. Taken together, these findings reveal that extracellular GABA and glutamate are differentially affected by BDNF, ethanol, age, and Mn." @default.
• W1605599114 created "2016-06-24" @default.
• W1605599114 creator A5027570971 @default.
• W1605599114 date "2011-01-01" @default.
• W1605599114 modified "2023-09-27" @default.
• W1605599114 title "Analysis of gaba and glutamate in the mouse dorsal striatum" @default.
• W1605599114 cites W1522048223 @default.
• W1605599114 cites W1522318572 @default.
• W1605599114 cites W1575167357 @default.
• W1605599114 cites W1963748364 @default.
• W1605599114 cites W1964499979 @default.
• W1605599114 cites W1972324310 @default.
• W1605599114 cites W1973820266 @default.
• W1605599114 cites W1983724220 @default.
• W1605599114 cites W1984503750 @default.
• W1605599114 cites W1986853673 @default.
• W1605599114 cites W1990293683 @default.
• W1605599114 cites W1993068285 @default.
• W1605599114 cites W1995865564 @default.
• W1605599114 cites W1998441599 @default.
• W1605599114 cites W1999238951 @default.
• W1605599114 cites W2000516728 @default.
• W1605599114 cites W2002238280 @default.
• W1605599114 cites W2005113925 @default.
• W1605599114 cites W2006433711 @default.
• W1605599114 cites W2014547400 @default.
• W1605599114 cites W2016106373 @default.
• W1605599114 cites W2016261812 @default.
• W1605599114 cites W2016477857 @default.
• W1605599114 cites W2017871117 @default.
• W1605599114 cites W2032442146 @default.
• W1605599114 cites W2037130161 @default.
• W1605599114 cites W2044136311 @default.
• W1605599114 cites W2049299981 @default.
• W1605599114 cites W2050697988 @default.
• W1605599114 cites W2055628150 @default.
• W1605599114 cites W2059082210 @default.
• W1605599114 cites W2060545591 @default.
• W1605599114 cites W2065154130 @default.
• W1605599114 cites W2067326872 @default.
• W1605599114 cites W2080431452 @default.
• W1605599114 cites W2081300613 @default.
• W1605599114 cites W2087688207 @default.
• W1605599114 cites W2092587709 @default.
• W1605599114 cites W2104064731 @default.
• W1605599114 cites W2114116729 @default.
• W1605599114 cites W2119569209 @default.
• W1605599114 cites W2138888765 @default.
• W1605599114 cites W2149091699 @default.
• W1605599114 cites W2407705184 @default.
• W1605599114 cites W38866710 @default.
• W1605599114 cites W72669700 @default.
• W1605599114 hasPublicationYear "2011" @default.
• W1605599114 type Work @default.
• W1605599114 sameAs 1605599114 @default.
• W1605599114 citedByCount "0" @default.
• W1605599114 crossrefType "journal-article" @default.
• W1605599114 hasAuthorship W1605599114A5027570971 @default.
• W1605599114 hasConcept C126322002 @default.
• W1605599114 hasConcept C134018914 @default.
• W1605599114 hasConcept C16613235 @default.
• W1605599114 hasConcept C169760540 @default.
• W1605599114 hasConcept C170493617 @default.
• W1605599114 hasConcept C17077164 @default.
• W1605599114 hasConcept C185592680 @default.
• W1605599114 hasConcept C2776219046 @default.
• W1605599114 hasConcept C2780062018 @default.
• W1605599114 hasConcept C2780648746 @default.
• W1605599114 hasConcept C28406088 @default.
• W1605599114 hasConcept C513476851 @default.
• W1605599114 hasConcept C529278444 @default.
• W1605599114 hasConcept C55493867 @default.
• W1605599114 hasConcept C61174792 @default.
• W1605599114 hasConcept C71924100 @default.
• W1605599114 hasConcept C86803240 @default.
• W1605599114 hasConcept C98274493 @default.
• W1605599114 hasConceptScore W1605599114C126322002 @default.
• W1605599114 hasConceptScore W1605599114C134018914 @default.
• W1605599114 hasConceptScore W1605599114C16613235 @default.
• W1605599114 hasConceptScore W1605599114C169760540 @default.
• W1605599114 hasConceptScore W1605599114C170493617 @default.
• W1605599114 hasConceptScore W1605599114C17077164 @default.
• W1605599114 hasConceptScore W1605599114C185592680 @default.
• W1605599114 hasConceptScore W1605599114C2776219046 @default.
• W1605599114 hasConceptScore W1605599114C2780062018 @default.
• W1605599114 hasConceptScore W1605599114C2780648746 @default.
• W1605599114 hasConceptScore W1605599114C28406088 @default.
• W1605599114 hasConceptScore W1605599114C513476851 @default.
• W1605599114 hasConceptScore W1605599114C529278444 @default.
• W1605599114 hasConceptScore W1605599114C55493867 @default.
• W1605599114 hasConceptScore W1605599114C61174792 @default.
• W1605599114 hasConceptScore W1605599114C71924100 @default.
• W1605599114 hasConceptScore W1605599114C86803240 @default.
• W1605599114 hasConceptScore W1605599114C98274493 @default.
• W1605599114 hasLocation W16055991141 @default.
• W1605599114 hasOpenAccess W1605599114 @default.
• W1605599114 hasPrimaryLocation W16055991141 @default.
• W1605599114 hasRelatedWork W176377221 @default.
• W1605599114 hasRelatedWork W1982601240 @default.
• W1605599114 hasRelatedWork W1990320001 @default.

• next