FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605657905> ?p ?o ?g. }

• W1605657905 abstract "Methylation interference and missing contact analyses demonstrate that nuclear factor I (NF I) recognizes an NF I-like site (5'-GGG(N)6GCCAG-3') within the alpha-globin promoter rather than the adjacent CCAAT box. Consistent with this, mutations within the CCAAT box do not alter significantly the affinity and specificity of the interaction whereas elimination of the 5'-GGG-3' half-site of the recognition sequence reduces the DNA binding strength of NF I by 2 orders of magnitude down to the range of unspecific interaction. On the other hand, the mutated alpha-globin promoter sequence that is no longer bound by NF I, although it retains an intact CCAAT box, interacts specifically with a protein component from nuclear extracts of HeLa cells. From these results we conclude that NF I is not the factor that interacts with the CCAAT box and that the second half of the canonical 5'-TGG(N)6GCCAA-3' NF I binding site cannot be regarded as identical with the CCAAT promoter element, as suggested previously." @default.
• W1605657905 created "2016-06-24" @default.
• W1605657905 creator A5011028978 @default.
• W1605657905 creator A5042379499 @default.
• W1605657905 creator A5045424288 @default.
• W1605657905 creator A5048232167 @default.
• W1605657905 creator A5084238530 @default.
• W1605657905 date "1992-04-01" @default.
• W1605657905 modified "2023-09-29" @default.
• W1605657905 title "Nuclear factor I (NF I) binds to an NF I-type site but not to the CCAAT site in the human alpha-globin gene promoter." @default.
• W1605657905 cites W1484339355 @default.
• W1605657905 cites W1489610462 @default.
• W1605657905 cites W1502910680 @default.
• W1605657905 cites W1507006450 @default.
• W1605657905 cites W1518599323 @default.
• W1605657905 cites W1548936220 @default.
• W1605657905 cites W1556012991 @default.
• W1605657905 cites W1559431187 @default.
• W1605657905 cites W1568940476 @default.
• W1605657905 cites W1615554109 @default.
• W1605657905 cites W1691146464 @default.
• W1605657905 cites W1881449691 @default.
• W1605657905 cites W1942467333 @default.
• W1605657905 cites W1951802529 @default.
• W1605657905 cites W1966002568 @default.
• W1605657905 cites W1970234384 @default.
• W1605657905 cites W1978881490 @default.
• W1605657905 cites W1983512144 @default.
• W1605657905 cites W1992614891 @default.
• W1605657905 cites W1993243592 @default.
• W1605657905 cites W1996075074 @default.
• W1605657905 cites W1996642589 @default.
• W1605657905 cites W1998108444 @default.
• W1605657905 cites W2002650712 @default.
• W1605657905 cites W2003893812 @default.
• W1605657905 cites W2012490729 @default.
• W1605657905 cites W2013249357 @default.
• W1605657905 cites W2021825044 @default.
• W1605657905 cites W2024018102 @default.
• W1605657905 cites W2027216583 @default.
• W1605657905 cites W2028927298 @default.
• W1605657905 cites W2035416523 @default.
• W1605657905 cites W2037824747 @default.
• W1605657905 cites W2038428233 @default.
• W1605657905 cites W2041185099 @default.
• W1605657905 cites W2045467759 @default.
• W1605657905 cites W2048356148 @default.
• W1605657905 cites W2054312963 @default.
• W1605657905 cites W2068394666 @default.
• W1605657905 cites W2072718264 @default.
• W1605657905 cites W2076134621 @default.
• W1605657905 cites W2077903723 @default.
• W1605657905 cites W2079714179 @default.
• W1605657905 cites W2085206941 @default.
• W1605657905 cites W2095248898 @default.
• W1605657905 cites W2109030204 @default.
• W1605657905 cites W2128569886 @default.
• W1605657905 cites W2129346720 @default.
• W1605657905 cites W2130535740 @default.
• W1605657905 cites W2157569342 @default.
• W1605657905 cites W2240323633 @default.
• W1605657905 cites W2290524938 @default.
• W1605657905 cites W26691815 @default.
• W1605657905 cites W4237406112 @default.
• W1605657905 cites W42654338 @default.
• W1605657905 cites W9260168 @default.
• W1605657905 cites W97754571 @default.
• W1605657905 doi "https://doi.org/10.1016/s0021-9258(18)42470-2" @default.
• W1605657905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1569098" @default.
• W1605657905 hasPublicationYear "1992" @default.
• W1605657905 type Work @default.
• W1605657905 sameAs 1605657905 @default.
• W1605657905 citedByCount "32" @default.
• W1605657905 countsByYear W16056579052012 @default.
• W1605657905 countsByYear W16056579052018 @default.
• W1605657905 countsByYear W16056579052019 @default.
• W1605657905 countsByYear W16056579052020 @default.
• W1605657905 countsByYear W16056579052021 @default.
• W1605657905 countsByYear W16056579052022 @default.
• W1605657905 crossrefType "journal-article" @default.
• W1605657905 hasAuthorship W1605657905A5011028978 @default.
• W1605657905 hasAuthorship W1605657905A5042379499 @default.
• W1605657905 hasAuthorship W1605657905A5045424288 @default.
• W1605657905 hasAuthorship W1605657905A5048232167 @default.
• W1605657905 hasAuthorship W1605657905A5084238530 @default.
• W1605657905 hasBestOaLocation W16056579051 @default.
• W1605657905 hasConcept C101762097 @default.
• W1605657905 hasConcept C104317684 @default.
• W1605657905 hasConcept C107824862 @default.
• W1605657905 hasConcept C121332964 @default.
• W1605657905 hasConcept C150194340 @default.
• W1605657905 hasConcept C153911025 @default.
• W1605657905 hasConcept C179716448 @default.
• W1605657905 hasConcept C29512474 @default.
• W1605657905 hasConcept C54355233 @default.
• W1605657905 hasConcept C86339819 @default.
• W1605657905 hasConcept C86803240 @default.
• W1605657905 hasConceptScore W1605657905C101762097 @default.
• W1605657905 hasConceptScore W1605657905C104317684 @default.
• W1605657905 hasConceptScore W1605657905C107824862 @default.

• next