Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605672032> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1605672032 endingPage "1334" @default.
- W1605672032 startingPage "1329" @default.
- W1605672032 abstract "Isatin, a stress-related biological substance, increases in rat urine in association with elevated catecholamine biosynthesis during stress. The goal of this study was to unravel how the biosynthetic pathway of isatin is related to stress response. The importance of the serotonergic compounds in anxiety, which is the major emotional process of stress response, has emerged. m-Chlorophenylpiperazine (m-CPP), a 5-HT(1A/1B/2A/2C) receptor agonist, and (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride [(+/-)-DOI], a 5-HT(2A/2C) agonist, both of which have anxiogenic properties, induced a marked increase in 24-hr urinary isatin excretion, whereas neither 1-(m-chlorophenyl)-biguanide (m-CPBG), a 5-HT3 agonist, nor 2-methyl-5-HT, a 5-HT(3,4) agonist, affected urinary isatin excretion. 5-HT(2A/2C) receptor antagonists such as ketanserin and ritanserin prevented the increase in urinary isatin excretion induced by the 5-HT(2A/2C) receptor agonist m-CPP. These findings are the first to provide evidence that pharmacological substances cause increases in urinary isatin excretion via specific 5-HT receptors, probably 5-HT(2A/2C) receptors. In addition, both the synthetic glucocorticoid dexamethasone and diazepam prevented the m-CPP-induced increase in urinary isatin excretion. These observations suggest that the mechanism by which m-CPP elicits enhancing effects on urinary isatin excretion has something in common with stress response involving activation of hypothalamic CRF cells and the sympathetic nervous system." @default.
- W1605672032 created "2016-06-24" @default.
- W1605672032 creator A5049300446 @default.
- W1605672032 creator A5050222497 @default.
- W1605672032 creator A5080266991 @default.
- W1605672032 creator A5087268697 @default.
- W1605672032 date "1999-10-01" @default.
- W1605672032 modified "2023-10-03" @default.
- W1605672032 title "5-HT2a/2c receptor agonist-induced increase in urinary isatin excretion in rats" @default.
- W1605672032 cites W1828428743 @default.
- W1605672032 cites W1976626089 @default.
- W1605672032 cites W1982852718 @default.
- W1605672032 cites W1983552236 @default.
- W1605672032 cites W1994092198 @default.
- W1605672032 cites W2000226054 @default.
- W1605672032 cites W2009973333 @default.
- W1605672032 cites W2024778632 @default.
- W1605672032 cites W2032646493 @default.
- W1605672032 cites W2032906429 @default.
- W1605672032 cites W2034116199 @default.
- W1605672032 cites W2034561886 @default.
- W1605672032 cites W2045082627 @default.
- W1605672032 cites W2046566573 @default.
- W1605672032 cites W2050423574 @default.
- W1605672032 cites W2054118318 @default.
- W1605672032 cites W2069806852 @default.
- W1605672032 cites W2072165349 @default.
- W1605672032 cites W2075144107 @default.
- W1605672032 cites W2136709982 @default.
- W1605672032 cites W2147281759 @default.
- W1605672032 cites W2153853866 @default.
- W1605672032 cites W2155624304 @default.
- W1605672032 cites W2157923688 @default.
- W1605672032 cites W2174758426 @default.
- W1605672032 cites W2419346387 @default.
- W1605672032 cites W25552167 @default.
- W1605672032 cites W2883849285 @default.
- W1605672032 cites W2499508917 @default.
- W1605672032 doi "https://doi.org/10.1016/s0006-2952(99)00195-1" @default.
- W1605672032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10487536" @default.
- W1605672032 hasPublicationYear "1999" @default.
- W1605672032 type Work @default.
- W1605672032 sameAs 1605672032 @default.
- W1605672032 citedByCount "5" @default.
- W1605672032 countsByYear W16056720322017 @default.
- W1605672032 countsByYear W16056720322022 @default.
- W1605672032 crossrefType "journal-article" @default.
- W1605672032 hasAuthorship W1605672032A5049300446 @default.
- W1605672032 hasAuthorship W1605672032A5050222497 @default.
- W1605672032 hasAuthorship W1605672032A5080266991 @default.
- W1605672032 hasAuthorship W1605672032A5087268697 @default.
- W1605672032 hasConcept C10146269 @default.
- W1605672032 hasConcept C126322002 @default.
- W1605672032 hasConcept C134018914 @default.
- W1605672032 hasConcept C170493617 @default.
- W1605672032 hasConcept C178790620 @default.
- W1605672032 hasConcept C185592680 @default.
- W1605672032 hasConcept C2777256644 @default.
- W1605672032 hasConcept C2778938600 @default.
- W1605672032 hasConcept C58732023 @default.
- W1605672032 hasConcept C71924100 @default.
- W1605672032 hasConcept C86803240 @default.
- W1605672032 hasConcept C98274493 @default.
- W1605672032 hasConceptScore W1605672032C10146269 @default.
- W1605672032 hasConceptScore W1605672032C126322002 @default.
- W1605672032 hasConceptScore W1605672032C134018914 @default.
- W1605672032 hasConceptScore W1605672032C170493617 @default.
- W1605672032 hasConceptScore W1605672032C178790620 @default.
- W1605672032 hasConceptScore W1605672032C185592680 @default.
- W1605672032 hasConceptScore W1605672032C2777256644 @default.
- W1605672032 hasConceptScore W1605672032C2778938600 @default.
- W1605672032 hasConceptScore W1605672032C58732023 @default.
- W1605672032 hasConceptScore W1605672032C71924100 @default.
- W1605672032 hasConceptScore W1605672032C86803240 @default.
- W1605672032 hasConceptScore W1605672032C98274493 @default.
- W1605672032 hasIssue "8" @default.
- W1605672032 hasLocation W16056720321 @default.
- W1605672032 hasLocation W16056720322 @default.
- W1605672032 hasOpenAccess W1605672032 @default.
- W1605672032 hasPrimaryLocation W16056720321 @default.
- W1605672032 hasRelatedWork W2014748341 @default.
- W1605672032 hasRelatedWork W2027913950 @default.
- W1605672032 hasRelatedWork W2034583712 @default.
- W1605672032 hasRelatedWork W2050423574 @default.
- W1605672032 hasRelatedWork W2052453588 @default.
- W1605672032 hasRelatedWork W2063619316 @default.
- W1605672032 hasRelatedWork W2074821979 @default.
- W1605672032 hasRelatedWork W2101411396 @default.
- W1605672032 hasRelatedWork W2164274035 @default.
- W1605672032 hasRelatedWork W2169225653 @default.
- W1605672032 hasVolume "58" @default.
- W1605672032 isParatext "false" @default.
- W1605672032 isRetracted "false" @default.
- W1605672032 magId "1605672032" @default.
- W1605672032 workType "article" @default.