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- W1605748609 abstract "Multinational clinical trials are trials conducted in more than one country using a common protocol. They have become increasingly common and have many advantages, such as access to a large patient population and the potential to obtain a broadly generalizable conclusion. However, these trials also have a number of practical difficulties, such as differences among the countries in language, import/export procedures, and regulatory and legal requirements. In addition, country-by-treatment interactions have frequently been found in these trials, leading to difficulties in interpreting the results. For example, the MERIT-HF trial, which evaluated metoprolol in patients with heart failure, found an overall hazard ratio for total mortality of 0.66, but a hazard ratio of 1.05 in the United States. There is particular concern that differences among countries hinder the ability to evaluate the cost effectiveness of an experimental treatment.Keywords:Cost effectiveness;country-by-treatment interaction;generalizability;health economic evaluation;MERIT-HF" @default.
- W1605748609 created "2016-06-24" @default.
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- W1605748609 date "2014-09-29" @default.
- W1605748609 modified "2023-09-26" @default.
- W1605748609 title "Multinational (Global) Trial" @default.
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- W1605748609 doi "https://doi.org/10.1002/9781118445112.stat07118" @default.
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