FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605785874> ?p ?o ?g. }

• W1605785874 endingPage "460" @default.
• W1605785874 startingPage "451" @default.
• W1605785874 abstract "Aims To investigate the effects of age and disease states on the expression and activity of intestinal CYP3A4 in a paediatric population. Methods Duodenal biopsies and surgical sections were collected from 104 paediatric patients (age range 2 weeks to 17 years) and from 11 foetuses. An S9 fraction was prepared in each case. CYP3A4 expression was assessed by Western blotting and by immunohistochemistry; activity was measured by the rate of formation of 6β‐hydroxytestosterone from testosterone. Villin expression was used as a marker of enterocyte harvest to normalize CYP3A4 expression and activity data. Results In the 74 histologically normal paediatric biopsies there were statistically significant increases in CYP3A4 expression ( r 2 = 0.19, P = 0.001) and activity ( r 2 = 0.17, P = 0.02) with age. CYP3A4 was practically absent in fetal duodenum and was expressed at relatively low levels in neonates ( P < 0.05 between neonates and children > 5 years). Active coeliac disease resulted in significant ( P < 0.001) decreases in CYP3A4 expression and activity. Conclusions Duodenal CYP3A4 is present at significantly lower levels in neonates and in patients with active coeliac disease. This may have clinical significance with respect to the oral bioavailability of CYP3A4 substrates." @default.
• W1605785874 created "2016-06-24" @default.
• W1605785874 creator A5026746931 @default.
• W1605785874 creator A5055372241 @default.
• W1605785874 creator A5067224766 @default.
• W1605785874 creator A5070835056 @default.
• W1605785874 date "2001-05-01" @default.
• W1605785874 modified "2023-10-18" @default.
• W1605785874 title "Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis" @default.
• W1605785874 cites W142299042 @default.
• W1605785874 cites W1569446437 @default.
• W1605785874 cites W172649764 @default.
• W1605785874 cites W1780915130 @default.
• W1605785874 cites W1901300892 @default.
• W1605785874 cites W1929292775 @default.
• W1605785874 cites W1963675686 @default.
• W1605785874 cites W1978921548 @default.
• W1605785874 cites W1985137868 @default.
• W1605785874 cites W1994728875 @default.
• W1605785874 cites W1998850038 @default.
• W1605785874 cites W2001341261 @default.
• W1605785874 cites W2002044083 @default.
• W1605785874 cites W2008617718 @default.
• W1605785874 cites W2009988670 @default.
• W1605785874 cites W2013822904 @default.
• W1605785874 cites W2017411996 @default.
• W1605785874 cites W2022435477 @default.
• W1605785874 cites W2022713088 @default.
• W1605785874 cites W2029627662 @default.
• W1605785874 cites W2030630876 @default.
• W1605785874 cites W2051175552 @default.
• W1605785874 cites W2057717414 @default.
• W1605785874 cites W2057734524 @default.
• W1605785874 cites W2065572118 @default.
• W1605785874 cites W2073965718 @default.
• W1605785874 cites W2077229986 @default.
• W1605785874 cites W2077510533 @default.
• W1605785874 cites W2082453607 @default.
• W1605785874 cites W2085646040 @default.
• W1605785874 cites W2086759143 @default.
• W1605785874 cites W2094975151 @default.
• W1605785874 cites W2102688834 @default.
• W1605785874 cites W2107567029 @default.
• W1605785874 cites W2141508925 @default.
• W1605785874 cites W2154012653 @default.
• W1605785874 cites W2163891284 @default.
• W1605785874 cites W2279936106 @default.
• W1605785874 cites W2290322369 @default.
• W1605785874 cites W2404223809 @default.
• W1605785874 cites W2415153267 @default.
• W1605785874 cites W4300011144 @default.
• W1605785874 cites W98066145 @default.
• W1605785874 cites W1526490082 @default.
• W1605785874 doi "https://doi.org/10.1046/j.1365-2125.2001.01370.x" @default.
• W1605785874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2014473" @default.
• W1605785874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11422003" @default.
• W1605785874 hasPublicationYear "2001" @default.
• W1605785874 type Work @default.
• W1605785874 sameAs 1605785874 @default.
• W1605785874 citedByCount "131" @default.
• W1605785874 countsByYear W16057858742012 @default.
• W1605785874 countsByYear W16057858742013 @default.
• W1605785874 countsByYear W16057858742014 @default.
• W1605785874 countsByYear W16057858742015 @default.
• W1605785874 countsByYear W16057858742016 @default.
• W1605785874 countsByYear W16057858742017 @default.
• W1605785874 countsByYear W16057858742018 @default.
• W1605785874 countsByYear W16057858742019 @default.
• W1605785874 countsByYear W16057858742020 @default.
• W1605785874 countsByYear W16057858742021 @default.
• W1605785874 countsByYear W16057858742022 @default.
• W1605785874 countsByYear W16057858742023 @default.
• W1605785874 crossrefType "journal-article" @default.
• W1605785874 hasAuthorship W1605785874A5026746931 @default.
• W1605785874 hasAuthorship W1605785874A5055372241 @default.
• W1605785874 hasAuthorship W1605785874A5067224766 @default.
• W1605785874 hasAuthorship W1605785874A5070835056 @default.
• W1605785874 hasBestOaLocation W16057858742 @default.
• W1605785874 hasConcept C109650736 @default.
• W1605785874 hasConcept C126322002 @default.
• W1605785874 hasConcept C134018914 @default.
• W1605785874 hasConcept C181389837 @default.
• W1605785874 hasConcept C2776809568 @default.
• W1605785874 hasConcept C2779134260 @default.
• W1605785874 hasConcept C2780349322 @default.
• W1605785874 hasConcept C2908647359 @default.
• W1605785874 hasConcept C42407357 @default.
• W1605785874 hasConcept C526171541 @default.
• W1605785874 hasConcept C62231903 @default.
• W1605785874 hasConcept C71924100 @default.
• W1605785874 hasConcept C90924648 @default.
• W1605785874 hasConcept C98274493 @default.
• W1605785874 hasConcept C99454951 @default.
• W1605785874 hasConceptScore W1605785874C109650736 @default.
• W1605785874 hasConceptScore W1605785874C126322002 @default.
• W1605785874 hasConceptScore W1605785874C134018914 @default.
• W1605785874 hasConceptScore W1605785874C181389837 @default.
• W1605785874 hasConceptScore W1605785874C2776809568 @default.

• next