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- W1605808712 abstract "Objectives: To investigate the decline per year in skin elasticity in postmenopausal women and how much hormone replacement therapy (HRT) increased elasticity over 12 months. Design: Observational study of convenience sample. Setting: The Cardiovascular Hospital of Central Japan, a cardiovascular medical center. Participants: One hundred seventy‐six postmenopausal subjects, mean age±standard deviation=61.3±9.1. Measurements: In Study 1, skin elasticity was measured in the right forearm using a suction device. Comparisons also were made with 45 premenopausal subjects (aged 34.5±9.9). Skin elasticity in the right forearm was measured using the same device at baseline and 12 months after initiation of HRT. Interventions: In Study 2, 12 postmenopausal subjects (mean age=57.1±7.4, range 49–71) received conjugated equine estrogen (0.625 mg/d) in combination with medroxyprogesterone acetate (2.5 mg/d) for 12 months. Results: In Study 1, significant negative correlations between skin elasticity and age and years since menopause were found ( r =−0.60, P <.001 for each), as well as a 0.55% decline per year in skin elasticity. In Study 2, 12 months of HRT significantly increased skin elasticity in postmenopausal subjects, by 5.2%. Conclusion: After menopause, skin elasticity declined 0.55% per year; 12 months of HRT increased elasticity by 5.2%." @default.
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- W1605808712 date "2004-05-24" @default.
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- W1605808712 title "Effects of Aging, Menopause, and Hormone Replacement Therapy on Forearm Skin Elasticity in Women" @default.
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- W1605808712 doi "https://doi.org/10.1111/j.1532-5415.2004.52262.x" @default.
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