FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605834420> ?p ?o ?g. }

• W1605834420 abstract "The principal function of the eye is to receive the light signal from the environment and transmit it to the brain to create vision. This requires that the structures of the eye involved in light transmission, such as the cornea and the lens, must be transparent. Unlike other tissues of the body, nutrients and oxygen supply to these structures must be accomplished without blood interference in transmission of light, i.e., these structures must be avascular. Apart from this, the eye must also maintain optimum pressure within the globe, which is important to give the rigidity necessary for optical alignment of the cornea, lens and the retina. The eye achieves this by the production, accumulation and circulation of a clear fluid called aqueous humor (AH). AH is produced by selective transfer of solutes and water from the blood plasma by a complex ocular epithelium, the ciliary epithelium. The fluid then accumulates in the two special compartments within the eye, and the excess leaves the globe to enter the blood through complex pressure dependent outflow pathways. This complex arrangement of production, accumulation and drainage of aqueous humor contributes to the nutrition and survival of the avascular tissues as well as to good optical properties of the eye. However, this also poses a problem in that any imbalance in the production and drainage of aqueous humor inevitably causes abnormal intraocular pressure (IOP). For example, in case of insufficient drainage, excess accumulation of fluid within the globe will raise the IOP to higher than the physiological level; a clinical condition called glaucoma. Abnormally high pressure causes death or degeneration of the light sensitive and signal transmitting tissues of the eye leading progressively to partial or complete blindness. Understanding the mechanism of AH secretion and its regulation is important to develop rational and target specific drugs for the treatment of glaucoma. In this chapter we will try to present the readers with a comprehensive and up to date description of the relevant ocular anatomy, physiology, biochemistry and pharmacology of AH secretion and its relevance to pathophysiology of ocular hypertension or glaucoma." @default.
• W1605834420 created "2016-06-24" @default.
• W1605834420 creator A5013597405 @default.
• W1605834420 creator A5023185614 @default.
• W1605834420 creator A5054997228 @default.
• W1605834420 date "2011-11-11" @default.
• W1605834420 modified "2023-09-28" @default.
• W1605834420 title "Mechanism of Aqueous Humor Secretion, Its Regulation and Relevance to Glaucoma" @default.
• W1605834420 cites W109158899 @default.
• W1605834420 cites W112004620 @default.
• W1605834420 cites W112803784 @default.
• W1605834420 cites W114204161 @default.
• W1605834420 cites W118958574 @default.
• W1605834420 cites W124029328 @default.
• W1605834420 cites W124195144 @default.
• W1605834420 cites W1269381231 @default.
• W1605834420 cites W139816550 @default.
• W1605834420 cites W1447701311 @default.
• W1605834420 cites W1487781413 @default.
• W1605834420 cites W1504492140 @default.
• W1605834420 cites W1509884519 @default.
• W1605834420 cites W1511733128 @default.
• W1605834420 cites W1511942027 @default.
• W1605834420 cites W1520627554 @default.
• W1605834420 cites W1523864517 @default.
• W1605834420 cites W1558376255 @default.
• W1605834420 cites W1578904753 @default.
• W1605834420 cites W1580579463 @default.
• W1605834420 cites W1662750915 @default.
• W1605834420 cites W1853165702 @default.
• W1605834420 cites W185891161 @default.
• W1605834420 cites W187093199 @default.
• W1605834420 cites W1889456496 @default.
• W1605834420 cites W1898187723 @default.
• W1605834420 cites W1963583141 @default.
• W1605834420 cites W1964241219 @default.
• W1605834420 cites W1964444582 @default.
• W1605834420 cites W1968762452 @default.
• W1605834420 cites W1970908896 @default.
• W1605834420 cites W1971337051 @default.
• W1605834420 cites W1971828635 @default.
• W1605834420 cites W1972642171 @default.
• W1605834420 cites W1973307569 @default.
• W1605834420 cites W1974491215 @default.
• W1605834420 cites W1974618780 @default.
• W1605834420 cites W1975686588 @default.
• W1605834420 cites W1976793267 @default.
• W1605834420 cites W1976825863 @default.
• W1605834420 cites W1977630136 @default.
• W1605834420 cites W1978387164 @default.
• W1605834420 cites W1979228875 @default.
• W1605834420 cites W1981772426 @default.
• W1605834420 cites W1985304723 @default.
• W1605834420 cites W1985967274 @default.
• W1605834420 cites W1986239743 @default.
• W1605834420 cites W1990824649 @default.
• W1605834420 cites W1991332502 @default.
• W1605834420 cites W1992113895 @default.
• W1605834420 cites W1993987801 @default.
• W1605834420 cites W1997215245 @default.
• W1605834420 cites W1997891362 @default.
• W1605834420 cites W2001149401 @default.
• W1605834420 cites W2003004086 @default.
• W1605834420 cites W2004519308 @default.
• W1605834420 cites W2004520295 @default.
• W1605834420 cites W2004648154 @default.
• W1605834420 cites W2005112859 @default.
• W1605834420 cites W2006097076 @default.
• W1605834420 cites W2006618734 @default.
• W1605834420 cites W2008970928 @default.
• W1605834420 cites W2011796275 @default.
• W1605834420 cites W2012257083 @default.
• W1605834420 cites W2013108548 @default.
• W1605834420 cites W2015112223 @default.
• W1605834420 cites W2016412491 @default.
• W1605834420 cites W2017646545 @default.
• W1605834420 cites W2018742376 @default.
• W1605834420 cites W2018748428 @default.
• W1605834420 cites W2019646745 @default.
• W1605834420 cites W2019934780 @default.
• W1605834420 cites W2025281072 @default.
• W1605834420 cites W2028824141 @default.
• W1605834420 cites W2032632597 @default.
• W1605834420 cites W2035396690 @default.
• W1605834420 cites W2035970224 @default.
• W1605834420 cites W2036329737 @default.
• W1605834420 cites W2037338004 @default.
• W1605834420 cites W2039112003 @default.
• W1605834420 cites W2039445266 @default.
• W1605834420 cites W204463790 @default.
• W1605834420 cites W2045709891 @default.
• W1605834420 cites W2047745129 @default.
• W1605834420 cites W2050167951 @default.
• W1605834420 cites W2050405284 @default.
• W1605834420 cites W2052028539 @default.
• W1605834420 cites W2052088012 @default.
• W1605834420 cites W2052384796 @default.
• W1605834420 cites W2057266151 @default.
• W1605834420 cites W2058113050 @default.
• W1605834420 cites W2058830580 @default.

• next