FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605843957> ?p ?o ?g. }

• W1605843957 abstract "The expression of β-catenin detectable by immunohistochemistry has been reported to be prognostically important in breast cancer. In this study, we investigated the mechanism by which β-catenin is regulated in breast cancer cells. Our analysis of the gene promoter of β-catenin revealed multiple putative STAT3 binding sites. In support of the concept that STAT3 is a transcriptional regulator for β-catenin, results from our chromatin immunoprecipitation studies showed that STAT3 binds to two of the three potential STAT3-binding sites in the gene promoter of β-catenin (-856 and -938). Using our generated MCF-7 cell clones that carry an inducible STAT3C construct, we found that the expression levels of STAT3C significantly correlated with the transcriptional activity of β-catenin. Similar observations were made when we subjected two breast cancer cell lines (MCF-7 and BT-474) to STAT3 knock-down or transient gene transfection of STAT3C. Using immunohistochemistry, we found that pSTAT3 and β-catenin significantly correlated with each other (p=0.003, Fisher's exact test) in a cohort of primary breast tumors (n=129). To conclude, our results support the concept that STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer, and these two proteins may cooperate with each other in exerting their oncogenic effects in these tumors." @default.
• W1605843957 created "2016-06-24" @default.
• W1605843957 creator A5032651018 @default.
• W1605843957 creator A5032920417 @default.
• W1605843957 creator A5055846059 @default.
• W1605843957 creator A5068603411 @default.
• W1605843957 creator A5077633685 @default.
• W1605843957 date "2010-07-25" @default.
• W1605843957 modified "2023-09-23" @default.
• W1605843957 title "STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer." @default.
• W1605843957 cites W1598867832 @default.
• W1605843957 cites W1966683700 @default.
• W1605843957 cites W1970262077 @default.
• W1605843957 cites W1972372574 @default.
• W1605843957 cites W1977207314 @default.
• W1605843957 cites W1983712244 @default.
• W1605843957 cites W1987909503 @default.
• W1605843957 cites W1991757566 @default.
• W1605843957 cites W1993017455 @default.
• W1605843957 cites W2002404925 @default.
• W1605843957 cites W2009707750 @default.
• W1605843957 cites W2019306466 @default.
• W1605843957 cites W2030556604 @default.
• W1605843957 cites W2033178140 @default.
• W1605843957 cites W2035431183 @default.
• W1605843957 cites W2037680161 @default.
• W1605843957 cites W2044992780 @default.
• W1605843957 cites W2049951346 @default.
• W1605843957 cites W2050933562 @default.
• W1605843957 cites W2054374001 @default.
• W1605843957 cites W2062096656 @default.
• W1605843957 cites W2062222985 @default.
• W1605843957 cites W2071516626 @default.
• W1605843957 cites W2074605890 @default.
• W1605843957 cites W2077282333 @default.
• W1605843957 cites W2080713919 @default.
• W1605843957 cites W2091722004 @default.
• W1605843957 cites W2101856908 @default.
• W1605843957 cites W2107648723 @default.
• W1605843957 cites W2109069210 @default.
• W1605843957 cites W2125410679 @default.
• W1605843957 cites W2132047377 @default.
• W1605843957 cites W2132633540 @default.
• W1605843957 cites W2141231260 @default.
• W1605843957 cites W2145617194 @default.
• W1605843957 cites W2167358033 @default.
• W1605843957 cites W2239090104 @default.
• W1605843957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933385" @default.
• W1605843957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20830236" @default.
• W1605843957 hasPublicationYear "2010" @default.
• W1605843957 type Work @default.
• W1605843957 sameAs 1605843957 @default.
• W1605843957 citedByCount "26" @default.
• W1605843957 countsByYear W16058439572012 @default.
• W1605843957 countsByYear W16058439572013 @default.
• W1605843957 countsByYear W16058439572014 @default.
• W1605843957 countsByYear W16058439572015 @default.
• W1605843957 countsByYear W16058439572016 @default.
• W1605843957 countsByYear W16058439572018 @default.
• W1605843957 countsByYear W16058439572019 @default.
• W1605843957 countsByYear W16058439572020 @default.
• W1605843957 countsByYear W16058439572021 @default.
• W1605843957 countsByYear W16058439572022 @default.
• W1605843957 countsByYear W16058439572023 @default.
• W1605843957 crossrefType "journal-article" @default.
• W1605843957 hasAuthorship W1605843957A5032651018 @default.
• W1605843957 hasAuthorship W1605843957A5032920417 @default.
• W1605843957 hasAuthorship W1605843957A5055846059 @default.
• W1605843957 hasAuthorship W1605843957A5068603411 @default.
• W1605843957 hasAuthorship W1605843957A5077633685 @default.
• W1605843957 hasConcept C101762097 @default.
• W1605843957 hasConcept C104317684 @default.
• W1605843957 hasConcept C121608353 @default.
• W1605843957 hasConcept C134320426 @default.
• W1605843957 hasConcept C137620995 @default.
• W1605843957 hasConcept C150194340 @default.
• W1605843957 hasConcept C153911025 @default.
• W1605843957 hasConcept C203014093 @default.
• W1605843957 hasConcept C204232928 @default.
• W1605843957 hasConcept C2778923194 @default.
• W1605843957 hasConcept C30145163 @default.
• W1605843957 hasConcept C502942594 @default.
• W1605843957 hasConcept C530470458 @default.
• W1605843957 hasConcept C54009773 @default.
• W1605843957 hasConcept C54355233 @default.
• W1605843957 hasConcept C86803240 @default.
• W1605843957 hasConceptScore W1605843957C101762097 @default.
• W1605843957 hasConceptScore W1605843957C104317684 @default.
• W1605843957 hasConceptScore W1605843957C121608353 @default.
• W1605843957 hasConceptScore W1605843957C134320426 @default.
• W1605843957 hasConceptScore W1605843957C137620995 @default.
• W1605843957 hasConceptScore W1605843957C150194340 @default.
• W1605843957 hasConceptScore W1605843957C153911025 @default.
• W1605843957 hasConceptScore W1605843957C203014093 @default.
• W1605843957 hasConceptScore W1605843957C204232928 @default.
• W1605843957 hasConceptScore W1605843957C2778923194 @default.
• W1605843957 hasConceptScore W1605843957C30145163 @default.
• W1605843957 hasConceptScore W1605843957C502942594 @default.
• W1605843957 hasConceptScore W1605843957C530470458 @default.
• W1605843957 hasConceptScore W1605843957C54009773 @default.

• next