FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1605856232> ?p ?o ?g. }

• W1605856232 endingPage "557" @default.
• W1605856232 startingPage "552" @default.
• W1605856232 abstract "We here report the apoptotic death of a fungus, Cryptococcus neoformans (C. neoformans), in response to adherence of the pathogenic bacterium Staphylococcus aureus (S. aureus). In co-culture, cryptococcal actin was visibly aggregated. To investigate the mechanism of death, the participation of small GTP(guanosine triphosphate)-binding proteins belonging to the Rho subfamily, which regulate the actin cytoskeleton, was explored. C. neoformans was cultured with S. aureus in the presence of N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide (Y-27632), an inhibitor of Rho-associated coiled-coil forming kinase (ROCK), a downstream effector of Rho. Death of C. neoformans was significantly reduced by the inhibitor. Concomitantly, Y-27632 prevented the aggregation of actin. Therefore, it was concluded that the Rho/ROCK pathway is involved in cell death induced by adherence stress. Increased expression of the voltage-dependent anion channel (VDAC), located in the mitochondrial outer membrane, has previously been observed in the apoptosis-like death of C. neoformans in the presence of hydrogen peroxide. Ruthenium red (RuR), which binds to VDAC and inhibits cytochrome c release, was used to determine the involvement of VDAC following adherence stress caused by S. aureus. RuR treatment increased the viability of C. neoformans co-cultured with S. aureus in a dose dependent manner. These findings suggest that Rho-ROCK signaling could be involved, via a mitochondrial pathway, in the apoptosis-like death of C. neoformans induced by the adherence of S. aureus." @default.
• W1605856232 created "2016-06-24" @default.
• W1605856232 creator A5065537761 @default.
• W1605856232 date "2011-07-28" @default.
• W1605856232 modified "2023-09-24" @default.
• W1605856232 title "Possible participation of the Rho/Rho-associated coiled-coil-forming kinase pathway in the cell death of Cryptococcus neoformans caused by Staphylococcus aureus adherence" @default.
• W1605856232 cites W1440841504 @default.
• W1605856232 cites W1502351927 @default.
• W1605856232 cites W1968336392 @default.
• W1605856232 cites W1974851340 @default.
• W1605856232 cites W1984058222 @default.
• W1605856232 cites W1985850372 @default.
• W1605856232 cites W1995757732 @default.
• W1605856232 cites W2007660746 @default.
• W1605856232 cites W2011837917 @default.
• W1605856232 cites W2024653035 @default.
• W1605856232 cites W2029262483 @default.
• W1605856232 cites W2050374206 @default.
• W1605856232 cites W2061879227 @default.
• W1605856232 cites W2074611001 @default.
• W1605856232 cites W2080629737 @default.
• W1605856232 cites W2088955328 @default.
• W1605856232 cites W2095013780 @default.
• W1605856232 cites W2095558727 @default.
• W1605856232 cites W2096002454 @default.
• W1605856232 cites W2098996804 @default.
• W1605856232 cites W2102679273 @default.
• W1605856232 cites W2121138608 @default.
• W1605856232 cites W2125510211 @default.
• W1605856232 cites W2126476309 @default.
• W1605856232 cites W2130853726 @default.
• W1605856232 cites W2131508801 @default.
• W1605856232 cites W2155522308 @default.
• W1605856232 cites W2157806162 @default.
• W1605856232 cites W2160262432 @default.
• W1605856232 cites W2162033191 @default.
• W1605856232 cites W2171190021 @default.
• W1605856232 doi "https://doi.org/10.1111/j.1348-0421.2011.00356.x" @default.
• W1605856232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21645052" @default.
• W1605856232 hasPublicationYear "2011" @default.
• W1605856232 type Work @default.
• W1605856232 sameAs 1605856232 @default.
• W1605856232 citedByCount "8" @default.
• W1605856232 countsByYear W16058562322013 @default.
• W1605856232 countsByYear W16058562322017 @default.
• W1605856232 countsByYear W16058562322018 @default.
• W1605856232 countsByYear W16058562322019 @default.
• W1605856232 countsByYear W16058562322020 @default.
• W1605856232 countsByYear W16058562322023 @default.
• W1605856232 crossrefType "journal-article" @default.
• W1605856232 hasAuthorship W1605856232A5065537761 @default.
• W1605856232 hasBestOaLocation W16058562321 @default.
• W1605856232 hasConcept C104317684 @default.
• W1605856232 hasConcept C142669718 @default.
• W1605856232 hasConcept C146587185 @default.
• W1605856232 hasConcept C1491633281 @default.
• W1605856232 hasConcept C190283241 @default.
• W1605856232 hasConcept C200784783 @default.
• W1605856232 hasConcept C2777893358 @default.
• W1605856232 hasConcept C2779489039 @default.
• W1605856232 hasConcept C2993400109 @default.
• W1605856232 hasConcept C31573885 @default.
• W1605856232 hasConcept C523546767 @default.
• W1605856232 hasConcept C54355233 @default.
• W1605856232 hasConcept C547475151 @default.
• W1605856232 hasConcept C55493867 @default.
• W1605856232 hasConcept C62478195 @default.
• W1605856232 hasConcept C86803240 @default.
• W1605856232 hasConcept C89423630 @default.
• W1605856232 hasConcept C95444343 @default.
• W1605856232 hasConceptScore W1605856232C104317684 @default.
• W1605856232 hasConceptScore W1605856232C142669718 @default.
• W1605856232 hasConceptScore W1605856232C146587185 @default.
• W1605856232 hasConceptScore W1605856232C1491633281 @default.
• W1605856232 hasConceptScore W1605856232C190283241 @default.
• W1605856232 hasConceptScore W1605856232C200784783 @default.
• W1605856232 hasConceptScore W1605856232C2777893358 @default.
• W1605856232 hasConceptScore W1605856232C2779489039 @default.
• W1605856232 hasConceptScore W1605856232C2993400109 @default.
• W1605856232 hasConceptScore W1605856232C31573885 @default.
• W1605856232 hasConceptScore W1605856232C523546767 @default.
• W1605856232 hasConceptScore W1605856232C54355233 @default.
• W1605856232 hasConceptScore W1605856232C547475151 @default.
• W1605856232 hasConceptScore W1605856232C55493867 @default.
• W1605856232 hasConceptScore W1605856232C62478195 @default.
• W1605856232 hasConceptScore W1605856232C86803240 @default.
• W1605856232 hasConceptScore W1605856232C89423630 @default.
• W1605856232 hasConceptScore W1605856232C95444343 @default.
• W1605856232 hasIssue "8" @default.
• W1605856232 hasLocation W16058562321 @default.
• W1605856232 hasLocation W16058562322 @default.
• W1605856232 hasOpenAccess W1605856232 @default.
• W1605856232 hasPrimaryLocation W16058562321 @default.
• W1605856232 hasRelatedWork W1989197268 @default.
• W1605856232 hasRelatedWork W2044753755 @default.
• W1605856232 hasRelatedWork W2045973628 @default.
• W1605856232 hasRelatedWork W2050844765 @default.
• W1605856232 hasRelatedWork W2055494323 @default.

• next