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- W1605908963 endingPage "4070" @default.
- W1605908963 startingPage "4060" @default.
- W1605908963 abstract "Epstein-Barr virus (EBV), a human oncogenic herpesvirus that establishes a lifelong latent infection in the host, occasionally enters lytic infection to produce progeny viruses. The EBV oncogene latent membrane protein 1 (LMP1), which is expressed in both latent and lytic infection, constitutively activates the canonical NF-κB (p65) pathway. Such LMP1-mediated NF-κB activation is necessary for proliferation of latently infected cells and inhibition of viral lytic cycle progression. Actually, canonical NF-κB target gene expression was suppressed upon the onset of lytic infection. TRAF6, which is activated by conjugation of polyubiquitin chains, associates with LMP1 to mediate NF-κB signal transduction. We have found that EBV-encoded BPLF1 interacts with and deubiquitinates TRAF6 to inhibit NF-κB signaling during lytic infection. HEK293 cells with BPLF1-deficient recombinant EBV exhibited poor viral DNA replication compared with the wild type. Furthermore, exogenous expression of BPLF1 or p65 knockdown in cells restored DNA replication of BPLF1-deficient viruses, indicating that EBV BPLF1 deubiquitinates TRAF6 to inhibit NF-κB signal transduction, leading to promotion of viral lytic DNA replication." @default.
- W1605908963 created "2016-06-24" @default.
- W1605908963 creator A5008921302 @default.
- W1605908963 creator A5021381992 @default.
- W1605908963 creator A5023342442 @default.
- W1605908963 creator A5051756402 @default.
- W1605908963 creator A5056869124 @default.
- W1605908963 creator A5069937286 @default.
- W1605908963 creator A5079347085 @default.
- W1605908963 creator A5091318748 @default.
- W1605908963 date "2013-04-01" @default.
- W1605908963 modified "2023-10-02" @default.
- W1605908963 title "Epstein-Barr Virus Deubiquitinase Downregulates TRAF6-Mediated NF-κB Signaling during Productive Replication" @default.
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- W1605908963 doi "https://doi.org/10.1128/jvi.02020-12" @default.
- W1605908963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3624234" @default.
- W1605908963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23365429" @default.
- W1605908963 hasPublicationYear "2013" @default.