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• W1605962828 endingPage "332" @default.
• W1605962828 startingPage "315" @default.
• W1605962828 abstract "Abstract Exposure to high levels of life stress is associated with opiate and psychostimulant use in humans, but a causal role has not been established and the mechanisms involved in this putative association are not known. Processes involved in drug addiction can be studied under controlled experimental conditions in laboratory animals, using the intravenous drug self-administration, conditioned place preference and reinstatement procedures. The intravenous drug self-administration and conditioned place preference procedures are regarded as suitable animal models of drug reinforcement, and the reinstatement procedure is an animal model of drug relapse. Our review of the findings from rat studies using these animal models indicates that while stressors are important modulators of opiate- and psychostimulant-reinforced behavior, the effects of stressors on behavior in the above models is stressor-specific, and to some degree also procedure-specific and drug-specific. We also review data from studies on the neuronal mechanisms involved in the effects of different stressors on opiate and psychostimulant self-administration, conditioned place preference and reinstatement. Finally, we briefly discuss the implications of the data reviewed for future research and for the treatment of drug addiction." @default.
• W1605962828 created "2016-06-24" @default.
• W1605962828 creator A5066436685 @default.
• W1605962828 creator A5072086960 @default.
• W1605962828 date "2005-01-01" @default.
• W1605962828 modified "2023-10-16" @default.
• W1605962828 title "The role of stress in opiate and psychostimulant addiction: evidence from animal models" @default.
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