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- W1605970516 abstract "Feedback control systems are ubiquitous in nature and maintain health as much in microbes as in man. Control loops are designed to constrain a function within a predetermined limit, and failure to do so results in the symptoms and signs associated with disease. The endocrine system is one category of control system whose function is to constrain the concentrations of substances in the blood such as hormones, glucose, and ions. The endocrine control loop, like any other control loop, comprises two components: (1) a comparator that compares the level of substance being controlled with the set point (optimum level) and (2) a generator which secretes the substance to be controlled. Examples of such control loops are pituitary-thyroid, pituitary–adrenal cortex, islet–liver/muscle, and parathyroid–kidney/bone. Medical diagnosis and management, if not always a science, is a rational art. The interpretation of endocrine function tests and the action taken in response to them demands a fundamental understanding of endocrine loop behavior. The principles of feedback loop function are well understood and described here in the context of endocrine disease." @default.
- W1605970516 created "2016-06-24" @default.
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- W1605970516 date "1997-01-01" @default.
- W1605970516 modified "2023-09-23" @default.
- W1605970516 title "Endocrine Feedback Control in Health and Disease" @default.
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- W1605970516 doi "https://doi.org/10.1016/s1569-2582(97)80028-1" @default.
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