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- W1606015308 abstract "Summary and Discussion Diphtheric toxin and antitoxin do not necessarily combine in a fixed proportion to form a “neutral” compound, as postulated by Ehrlich and by Arrhenius and Madsen. Conforming to other antigen-antibody systems, both reagents seem multivalent with respect to each other. In the presence of an excess of toxin, antitoxin binds several times as much toxin as is indicated by its neutralizing activity, and the resulting compound is itself toxic. Similarly, in the presence of excess antitoxin, toxin combines with more than the neutralizing quantity of antitoxin to form an antitoxic compound. The precisely neutral compound, instead of being the usual type of combination, is formed only when the two reagents are mixed in just the proper proportions. The present experiments offer no clue as to the stoichiometric ratio between toxin and antitoxin at this point of equivalence (neutrality); nor do they indicate the number of reacting groups which bind each molecule of toxin and antitoxin at the equivalence point." @default.
- W1606015308 created "2016-06-24" @default.
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- W1606015308 date "1937-02-01" @default.
- W1606015308 modified "2023-09-25" @default.
- W1606015308 title "On the Mutual Multivalence of Toxin and Antitoxin" @default.
- W1606015308 doi "https://doi.org/10.4049/jimmunol.32.2.119" @default.
- W1606015308 hasPublicationYear "1937" @default.
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