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- W1606156741 abstract "Copper acetate solution was administered intravenously to two male infants with Menkes kinky hair syndrome at the age of 4 and 10 months, respectively. The serum copper and ceruloplasmin levels in these cases were markedly low. After copper acetate was initially given by intravenous drip in dose of 180μg/kg every other day, transient adverse reactions attributable to copper such as anemia, hematemesis and bloody stools appeared in one of the patients. These acute copper poisonings disappeared and the general condition was improved after blood transfusion was given. Then copper acetate was administered again slowly (5-6 hours) in dose of 90μg/kg every other day, but no signs of copper poisoning were observed. The serum copper and ceruloplasmin levels increased, then decreased to the normal levels 5-6 weeks after the administration. Further, the administration of copper caused activation of the movement of extremities, but brain damage was not improved." @default.
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- W1606156741 date "1979-01-01" @default.
- W1606156741 modified "2023-09-26" @default.
- W1606156741 title "Treatment of Hypocupreinemia and Hypoceruloplasminemia-Menkes Kinky Hair Syndrome-with Intravenous Copper Acetate Infusion" @default.
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- W1606156741 doi "https://doi.org/10.5649/jjphcs1975.4.214" @default.
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