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- W1606207132 abstract "We recently reported that dietary fenugreek seeds lower the incidence of cholesterol gallstones (CGS) in high-cholesterol fed mice and also regress pre-established CGS. In this study, fenugreek was evaluated for hepatoprotective and antioxidant influence in mice fed high-cholesterol diet (HCD). After feeding HCD for 10 weeks, groups of animals were maintained for further 10 weeks on HCD/basal diet/basal diet containing 6 or 12% fenugreek. Activities of serum aspartate aminotrasferase, alanine aminotransferase, lactate dehydrogenase and alkaline phosphatase increased with prolonged feeding of HCD. Activities of these enzymes were lower in animals fed basal control/ fenugreek containing diets after initial exposure to HCD, and were prominent in fenugreek groups. Hepatic lipid peroxides decreased and antioxidant molecules increased in fenugreek fed groups. Activities of hepatic antioxidant enzymes – glutathione reductase, glutathione-S-transferase and glutathione peroxidase were higher in fenugreek treatment. These results suggested hepatoprotective and antioxidant potential of fenugreek seeds under conditions of lithogenicity.PRACTICAL APPLICATIONSThis animal study has indicated the health beneficial hepatoprotective and antioxidant influence of dietary fenugreek seeds in mice that had been previously chronically exposed to a high-cholesterol diet. These antioxidant effects of dietary fenugreek seeds are complementary to the recently reported reduction in the formation of cholesterol gallstones and regression of established cholesterol gallstones under lithogenic condition, namely, high cholesterol consumption and these effects were brought about by countering of the altered cholesterol saturation index in the bile by dietary fenugreek. The present novel report on the antioxidant influence of fenugreek seeds in conditions of oxidative stress brought about in hypercholesterolemia and lithogenic situation has an implication in deriving human health benefit of this spice adjuvant." @default.
- W1606207132 created "2016-06-24" @default.
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- W1606207132 date "2011-10-27" @default.
- W1606207132 modified "2023-10-17" @default.
- W1606207132 title "HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF FENUGREEK (TRIGONELLA FOENUM-GRAECUM) SEEDS IN MICE UNDER LITHOGENIC CONDITION" @default.
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- W1606207132 doi "https://doi.org/10.1111/j.1745-4514.2010.00488.x" @default.
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