FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1606345251> ?p ?o ?g. }

• W1606345251 abstract "Solid lipid nanoparticles have been increasingly utilised for improving oral bioavailability of drugs. Simvastatin is biopharmaceutical class 2 drug with poor oral bioavailability of 5%. In the present study, simvastatin solid lipid nanoparticles were successfully prepared by hot melt emulsification process and optimised with respect to surfactant and lipid concentration, and drug loading. The nanoparticles were characterised for entrapment efficiency, particle size, morphology, crystallinity and thermal behavior. Optimised formulations prepared from solid lipids glyceryl behenate and glyceryl palmitostearate containing Tween 80 as surfactant exhibited satisfactory entrapment efficiencies above 96% and mean particle size below 200 nm. The electron micrographs indicated that lipid nanocarriers were almost spherical in appearance. X-ray diffraction and differential calorimetric studies proved that the drug was amorphised in the lipid matrix and did not crystallise out. To improve the physical as well as chemical stability of formulations, dry adsorbed nanoparticles were prepared by evaporative drying method using a carrier. The adsorbed nanoparticles demonstrated good flow properties and satisfactory reconstitution properties. Pharmacodynamic studies of simvastatin solid lipid nanoparticles revealed improved reduction in total cholesterol values as compared to pure drug powder indicating improved bioavailability." @default.
• W1606345251 created "2016-06-24" @default.
• W1606345251 creator A5019283106 @default.
• W1606345251 creator A5041774229 @default.
• W1606345251 date "2013-09-01" @default.
• W1606345251 modified "2023-09-29" @default.
• W1606345251 title "Simvastatin Solid Lipid Nanoparticles for Oral Delivery: Formulation Development and In vivo Evaluation." @default.
• W1606345251 cites W1579046626 @default.
• W1606345251 cites W1965845975 @default.
• W1606345251 cites W2017214717 @default.
• W1606345251 cites W2018126221 @default.
• W1606345251 cites W2025946242 @default.
• W1606345251 cites W2038365601 @default.
• W1606345251 cites W2045422927 @default.
• W1606345251 cites W2050029045 @default.
• W1606345251 cites W2051541743 @default.
• W1606345251 cites W2073983855 @default.
• W1606345251 cites W2091024871 @default.
• W1606345251 cites W2107757278 @default.
• W1606345251 cites W2117576781 @default.
• W1606345251 cites W2142404968 @default.
• W1606345251 cites W2144417922 @default.
• W1606345251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3877522" @default.
• W1606345251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24403661" @default.
• W1606345251 hasPublicationYear "2013" @default.
• W1606345251 type Work @default.
• W1606345251 sameAs 1606345251 @default.
• W1606345251 citedByCount "25" @default.
• W1606345251 countsByYear W16063452512015 @default.
• W1606345251 countsByYear W16063452512016 @default.
• W1606345251 countsByYear W16063452512018 @default.
• W1606345251 countsByYear W16063452512019 @default.
• W1606345251 countsByYear W16063452512020 @default.
• W1606345251 countsByYear W16063452512021 @default.
• W1606345251 countsByYear W16063452512022 @default.
• W1606345251 countsByYear W16063452512023 @default.
• W1606345251 crossrefType "journal-article" @default.
• W1606345251 hasAuthorship W1606345251A5019283106 @default.
• W1606345251 hasAuthorship W1606345251A5041774229 @default.
• W1606345251 hasConcept C127413603 @default.
• W1606345251 hasConcept C147789679 @default.
• W1606345251 hasConcept C155672457 @default.
• W1606345251 hasConcept C159985019 @default.
• W1606345251 hasConcept C171250308 @default.
• W1606345251 hasConcept C181389837 @default.
• W1606345251 hasConcept C18150654 @default.
• W1606345251 hasConcept C185592680 @default.
• W1606345251 hasConcept C187530423 @default.
• W1606345251 hasConcept C192562407 @default.
• W1606345251 hasConcept C199529486 @default.
• W1606345251 hasConcept C2776329913 @default.
• W1606345251 hasConcept C42360764 @default.
• W1606345251 hasConcept C43617362 @default.
• W1606345251 hasConcept C46275449 @default.
• W1606345251 hasConcept C55493867 @default.
• W1606345251 hasConcept C58226133 @default.
• W1606345251 hasConcept C71924100 @default.
• W1606345251 hasConcept C98274493 @default.
• W1606345251 hasConceptScore W1606345251C127413603 @default.
• W1606345251 hasConceptScore W1606345251C147789679 @default.
• W1606345251 hasConceptScore W1606345251C155672457 @default.
• W1606345251 hasConceptScore W1606345251C159985019 @default.
• W1606345251 hasConceptScore W1606345251C171250308 @default.
• W1606345251 hasConceptScore W1606345251C181389837 @default.
• W1606345251 hasConceptScore W1606345251C18150654 @default.
• W1606345251 hasConceptScore W1606345251C185592680 @default.
• W1606345251 hasConceptScore W1606345251C187530423 @default.
• W1606345251 hasConceptScore W1606345251C192562407 @default.
• W1606345251 hasConceptScore W1606345251C199529486 @default.
• W1606345251 hasConceptScore W1606345251C2776329913 @default.
• W1606345251 hasConceptScore W1606345251C42360764 @default.
• W1606345251 hasConceptScore W1606345251C43617362 @default.
• W1606345251 hasConceptScore W1606345251C46275449 @default.
• W1606345251 hasConceptScore W1606345251C55493867 @default.
• W1606345251 hasConceptScore W1606345251C58226133 @default.
• W1606345251 hasConceptScore W1606345251C71924100 @default.
• W1606345251 hasConceptScore W1606345251C98274493 @default.
• W1606345251 hasLocation W16063452511 @default.
• W1606345251 hasOpenAccess W1606345251 @default.
• W1606345251 hasPrimaryLocation W16063452511 @default.
• W1606345251 hasRelatedWork W1236654308 @default.
• W1606345251 hasRelatedWork W1498305210 @default.
• W1606345251 hasRelatedWork W1579046626 @default.
• W1606345251 hasRelatedWork W1589827172 @default.
• W1606345251 hasRelatedWork W1977755432 @default.
• W1606345251 hasRelatedWork W2013630484 @default.
• W1606345251 hasRelatedWork W2044903986 @default.
• W1606345251 hasRelatedWork W2046017386 @default.
• W1606345251 hasRelatedWork W2054189154 @default.
• W1606345251 hasRelatedWork W2073778158 @default.
• W1606345251 hasRelatedWork W2073983855 @default.
• W1606345251 hasRelatedWork W2086732459 @default.
• W1606345251 hasRelatedWork W2160651357 @default.
• W1606345251 hasRelatedWork W2275714481 @default.
• W1606345251 hasRelatedWork W2790125956 @default.
• W1606345251 hasRelatedWork W2986242463 @default.
• W1606345251 hasRelatedWork W3119491536 @default.
• W1606345251 hasRelatedWork W3212426483 @default.
• W1606345251 hasRelatedWork W2182869113 @default.
• W1606345251 hasRelatedWork W2557448133 @default.

• next