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• W1606348064 abstract "Abstract 1. 1. Active transport of amino acids in rat kidney cortex slices diminished as the Na+ concentration of the medium was decreased below physiologic levels. In Na+-free media, active transport of glycine and α-amino [ i -14C]isobutyric acid was abolished, but active transport of lysine persisted. 2. 2. Lysine transport was found to be mediated by two mechanisms—one Na+ dependent and ouabain sensitive, and the other independent of Na+ and insensitive to ouabain. 3. 3. Maximal transport of amino acids occurred over a narrow range of medium K+ concentrations, falling off at higher and lower K+ levels. 4. 4. Substitution of other ions for Na+ in the medium caused significant alterations of the intracellular and extracellular fluid spaces of the tissues. 5. 5. Replacement of medium Na+ by K+ resulted in tissue swelling and suppression of amino acid transport beyond that caused by the absence of Na+. 6. 6. The common ionic requirements of kidney ATPase systems and of the mechanisms for active transport of certain amino acids suggest that these processes may be intimately related." @default.
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• W1606348064 date "1964-01-01" @default.
• W1606348064 modified "2023-09-23" @default.
• W1606348064 title "Ionic requirements for amino acid transport in the rat kidney cortex slice" @default.
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• W1606348064 doi "https://doi.org/10.1016/0926-6577(64)90049-x" @default.
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