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- W1606413595 abstract "Islets are innervated by parasympathetic, sympathetic, and sensory nerves. Parasympathetic nerves stimulate insulin and glucagon secretion, whereas sympathetic nerves inhibit insulin secretion and stimulate glucagon secretion; the net influence of the sensory nerves is not yet clearly established. Besides the classical neurotransmitters, noradrenaline and acetylcholine, the islet autonomic nerves also release neuropeptides, such as PACAP, VIP, GRP, galanin, NPY, CGRP, and substance P, which can also influence islet hormone secretion. The autonomic nerves may be of physiologic importance for the early phase of feeding and the stimulation of glucagon secretion during hypoglycemia. However, several important questions remain to be answered to fully understand the role of the autonomic nerves, in general, and their neuropeptides, in particular, in the control of islet function. This chapter summarizes the present-day knowledge and outlines important research avenues for the future." @default.
- W1606413595 created "2016-06-24" @default.
- W1606413595 creator A5027109387 @default.
- W1606413595 date "2015-03-06" @default.
- W1606413595 modified "2023-10-16" @default.
- W1606413595 title "Neuropeptides and islet hormone secretion" @default.
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- W1606413595 doi "https://doi.org/10.1002/9781118387658.ch9" @default.
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