Matches in SemOpenAlex for { <https://semopenalex.org/work/W1606423718> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1606423718 endingPage "36" @default.
- W1606423718 startingPage "123" @default.
- W1606423718 abstract "An in vitro reaction between mouse lymphoid cells and target fibroblastic cells in wells of microtest plates is described, which appears to simulate the in vivo rejection of haemopoietic allografts. Lymphoid cells from non-immunized mice were incubated with L929 or skeletal muscle fibroblasts, the latter from mouse embryos, in 0.02 ml volumes for 18–24 hours. Cell detachment was the measure of cytotoxicity, as the remaining adherent fibroblastic cells were enumerated in plates stained with Giemsa's stain. Cytotoxicity was related to the ratio of lymphoid cells to target cells plated (250:1 was the minimal ratio resulting in consistent cell damage) and to the length of time the two cell populations were incubated together. Neither extrinsic complement nor phytohaemagglutinin was necessary for the response. The lymphoid cells remained cytotoxic following exposure to 1000 R of X-radiation and were only slightly inhibited by rabbit antimouse thymocyte serum. Lymphoid cells from suckling mice were less effective than those from adults. Cyclophosphamide treatment suppressed the function and/or numbers of effective lymphoid cells. Differentiation of competent lymphoid cells from transplanted marrow stem cells was not inhibited by previous thymectomy of the recipient mice. Lymphoid cells were not cytotoxic for syngeneic target cells and were cytotoxic for allogeneic target cells. (C3H/He × C57BL/10Cz) F1 lymphoid cells were effective against C57BL/10Cz, but not C3H/He, target fibroblastic cells, demonstrating immunogenetic specific `hybrid resistance'." @default.
- W1606423718 created "2016-06-24" @default.
- W1606423718 creator A5018977802 @default.
- W1606423718 creator A5023550499 @default.
- W1606423718 date "1971-07-01" @default.
- W1606423718 modified "2023-10-18" @default.
- W1606423718 title "An in vitro reaction between lymphoid cells and target fibroblastic cells: a possible model for in vivo rejection of haemopoietic allografts." @default.
- W1606423718 cites W1490983695 @default.
- W1606423718 cites W1490991718 @default.
- W1606423718 cites W1517816850 @default.
- W1606423718 cites W1779894790 @default.
- W1606423718 cites W1818711052 @default.
- W1606423718 cites W1973647958 @default.
- W1606423718 cites W1976455557 @default.
- W1606423718 cites W2012744239 @default.
- W1606423718 cites W2035111364 @default.
- W1606423718 cites W2035889276 @default.
- W1606423718 cites W2048991282 @default.
- W1606423718 cites W2062815579 @default.
- W1606423718 cites W2074454870 @default.
- W1606423718 cites W2101885480 @default.
- W1606423718 cites W2103984051 @default.
- W1606423718 cites W2127458742 @default.
- W1606423718 cites W2168769056 @default.
- W1606423718 cites W2169773147 @default.
- W1606423718 cites W2407203997 @default.
- W1606423718 cites W2462955806 @default.
- W1606423718 cites W2471270490 @default.
- W1606423718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1408110" @default.
- W1606423718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4934136" @default.
- W1606423718 hasPublicationYear "1971" @default.
- W1606423718 type Work @default.
- W1606423718 sameAs 1606423718 @default.
- W1606423718 citedByCount "0" @default.
- W1606423718 crossrefType "journal-article" @default.
- W1606423718 hasAuthorship W1606423718A5018977802 @default.
- W1606423718 hasAuthorship W1606423718A5023550499 @default.
- W1606423718 hasConcept C109316439 @default.
- W1606423718 hasConcept C142724271 @default.
- W1606423718 hasConcept C150903083 @default.
- W1606423718 hasConcept C153911025 @default.
- W1606423718 hasConcept C154317977 @default.
- W1606423718 hasConcept C181152851 @default.
- W1606423718 hasConcept C202751555 @default.
- W1606423718 hasConcept C203014093 @default.
- W1606423718 hasConcept C207001950 @default.
- W1606423718 hasConcept C2780050583 @default.
- W1606423718 hasConcept C55493867 @default.
- W1606423718 hasConcept C71924100 @default.
- W1606423718 hasConcept C86803240 @default.
- W1606423718 hasConcept C8891405 @default.
- W1606423718 hasConceptScore W1606423718C109316439 @default.
- W1606423718 hasConceptScore W1606423718C142724271 @default.
- W1606423718 hasConceptScore W1606423718C150903083 @default.
- W1606423718 hasConceptScore W1606423718C153911025 @default.
- W1606423718 hasConceptScore W1606423718C154317977 @default.
- W1606423718 hasConceptScore W1606423718C181152851 @default.
- W1606423718 hasConceptScore W1606423718C202751555 @default.
- W1606423718 hasConceptScore W1606423718C203014093 @default.
- W1606423718 hasConceptScore W1606423718C207001950 @default.
- W1606423718 hasConceptScore W1606423718C2780050583 @default.
- W1606423718 hasConceptScore W1606423718C55493867 @default.
- W1606423718 hasConceptScore W1606423718C71924100 @default.
- W1606423718 hasConceptScore W1606423718C86803240 @default.
- W1606423718 hasConceptScore W1606423718C8891405 @default.
- W1606423718 hasIssue "1" @default.
- W1606423718 hasLocation W16064237181 @default.
- W1606423718 hasOpenAccess W1606423718 @default.
- W1606423718 hasPrimaryLocation W16064237181 @default.
- W1606423718 hasRelatedWork W1566729005 @default.
- W1606423718 hasRelatedWork W2005835527 @default.
- W1606423718 hasRelatedWork W2116210813 @default.
- W1606423718 hasRelatedWork W2138350991 @default.
- W1606423718 hasRelatedWork W2386538333 @default.
- W1606423718 hasRelatedWork W2409285845 @default.
- W1606423718 hasRelatedWork W2433842723 @default.
- W1606423718 hasRelatedWork W2434195791 @default.
- W1606423718 hasRelatedWork W2788599012 @default.
- W1606423718 hasRelatedWork W3015376786 @default.
- W1606423718 hasVolume "21" @default.
- W1606423718 isParatext "false" @default.
- W1606423718 isRetracted "false" @default.
- W1606423718 magId "1606423718" @default.
- W1606423718 workType "article" @default.