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• W1606504361 abstract "In the present study gross and microscopic findings due to the effects of various atherogenic and high-fat diets, together with various chronic and acute X-irradiation doses were compared in CFi male mice. The synthetic diets utilized in the present studies, high-fat synthetic control diet (C), Thomas (D), Fillios (E), or Wilgram (F), produced severe pathological disturbances in non-irradiated and irradiated animals. The weight of the liver and spleen in particular was decreased in mice fed atherogenic or synthetic control diets. Chronic radiation exposure either alone or in combination with diet C, F, or B caused marked decrease in the testis weights. Arterial lesions were easily produced in mice which were fed Wilgram diet and were similar to those described by him in rats. This appeared to be the first induction of atherosclerosis in mice using this diet. Comparison of the histopathological findings described in rats by Fillios, Thomas and Hartroft was impossible in mice because of their short survival. Without modification these diets appeared to be unsuitable for mouse experimentation. Lipid deposition within the smooth muscle cells was observed in the aorta, coronary and renal arteries in the mice fed diet F. In the mice fed atherogenic diets (D, F) severe atrophy of smooth muscle cells was seen and calcification of media of the aorta, coronary, renal and pulmonary arteries was frequent and severe. In addition, patchy calcified necrotic areas of myocardium were observed. However, the combination of the chronic irradiation exposure and diet F decreased the degree of lipid deposition and resulted in less calcification of the blood vessels. The same combination increased incidence of thrombosis. In using only chronic X-irradiation, mild hyalinization of collagen fibers in the aorta and calcification of coronary and testicular arteries were observed. Intimai lipid deposition was present in coronary arteries, as well as focal mononuclear infiltration, patchy necrosis and calcification in the myocardium. Acute radiation resulted in loss of smooth muscle cells and calcification of aortic media, calcification and hyalinization of the pulmonary arteries and mononuclear infiltration, necrosis and calcification of the myocardium. The combination of atherogenic diets with acute X-irradiation did not lead to any decrease in sudanophilia or calcification of blood vessels." @default.
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• W1606504361 date "1968-01-01" @default.
• W1606504361 modified "2023-09-26" @default.
• W1606504361 title "Experimental production of atherosclerosis in mice" @default.
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• W1606504361 doi "https://doi.org/10.1016/s0368-1319(68)80105-x" @default.
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