Matches in SemOpenAlex for { <https://semopenalex.org/work/W1606673973> ?p ?o ?g. }
- W1606673973 endingPage "193" @default.
- W1606673973 startingPage "177" @default.
- W1606673973 abstract "Myelin plays a critical role in proper neuronal function by providing trophic and metabolic support to axons and facilitating energy-efficient saltatory conduction. Myelination is influenced by numerous molecules including growth factors, hormones, transmembrane receptors and extracellular molecules, which activate signaling cascades that drive cellular maturation. Key signaling molecules and downstream signaling cascades controlling myelination have been identified in cell culture systems. However, in vitro systems are not able to faithfully replicate the complex in vivo signaling environment that occurs during development or following injury. Currently, it remains time-consuming and expensive to investigate myelination in vivo in rodents, the most widely used model for studying mammalian myelination. As such, there is a need for alternative in vivo myelination models, particularly ones that can test molecular mechanisms without removing oligodendrocyte lineage cells from their native signaling environment or disrupting intercellular interactions with other cell types present during myelination. Here, we review the ever-increasing role of zebrafish in studies uncovering novel mechanisms controlling vertebrate myelination. These innovative studies range from observations of the behavior of single cells during in vivo myelination as well as mutagenesis- and pharmacology-based screens in whole animals. Additionally, we discuss recent efforts to develop novel models of demyelination and oligodendrocyte cell death in adult zebrafish for the study of cellular behavior in real time during repair and regeneration of damaged nervous systems. GLIA 2015;63:177–193" @default.
- W1606673973 created "2016-06-24" @default.
- W1606673973 creator A5001351786 @default.
- W1606673973 creator A5062518246 @default.
- W1606673973 date "2014-09-27" @default.
- W1606673973 modified "2023-10-05" @default.
- W1606673973 title "Zebrafish as a model to investigate CNS myelination" @default.
- W1606673973 cites W1490936260 @default.
- W1606673973 cites W1593886923 @default.
- W1606673973 cites W1857560941 @default.
- W1606673973 cites W1964698151 @default.
- W1606673973 cites W1965545778 @default.
- W1606673973 cites W1965847248 @default.
- W1606673973 cites W1966880041 @default.
- W1606673973 cites W1966901116 @default.
- W1606673973 cites W1967873216 @default.
- W1606673973 cites W1968465823 @default.
- W1606673973 cites W1973807758 @default.
- W1606673973 cites W1973848776 @default.
- W1606673973 cites W1978855174 @default.
- W1606673973 cites W1979246833 @default.
- W1606673973 cites W1980798466 @default.
- W1606673973 cites W1981000616 @default.
- W1606673973 cites W1981239255 @default.
- W1606673973 cites W1981443842 @default.
- W1606673973 cites W1982691004 @default.
- W1606673973 cites W1982969769 @default.
- W1606673973 cites W1983140808 @default.
- W1606673973 cites W1984393899 @default.
- W1606673973 cites W1987301261 @default.
- W1606673973 cites W1987969211 @default.
- W1606673973 cites W1988180591 @default.
- W1606673973 cites W1990853566 @default.
- W1606673973 cites W1991702744 @default.
- W1606673973 cites W1992938999 @default.
- W1606673973 cites W1994712189 @default.
- W1606673973 cites W1995101000 @default.
- W1606673973 cites W1998198360 @default.
- W1606673973 cites W1998700159 @default.
- W1606673973 cites W1998756807 @default.
- W1606673973 cites W2000582303 @default.
- W1606673973 cites W2001810970 @default.
- W1606673973 cites W2006161539 @default.
- W1606673973 cites W2006951895 @default.
- W1606673973 cites W2007094970 @default.
- W1606673973 cites W2007435978 @default.
- W1606673973 cites W2013807114 @default.
- W1606673973 cites W2014493557 @default.
- W1606673973 cites W2017042997 @default.
- W1606673973 cites W2018936216 @default.
- W1606673973 cites W2019751519 @default.
- W1606673973 cites W2020788680 @default.
- W1606673973 cites W2023459835 @default.
- W1606673973 cites W2024470896 @default.
- W1606673973 cites W2025477103 @default.
- W1606673973 cites W2025548291 @default.
- W1606673973 cites W2027054509 @default.
- W1606673973 cites W2027830942 @default.
- W1606673973 cites W2031649134 @default.
- W1606673973 cites W2032054191 @default.
- W1606673973 cites W2034614910 @default.
- W1606673973 cites W2039055179 @default.
- W1606673973 cites W2039478755 @default.
- W1606673973 cites W2042472279 @default.
- W1606673973 cites W2043479124 @default.
- W1606673973 cites W2045070954 @default.
- W1606673973 cites W2045770060 @default.
- W1606673973 cites W2047899819 @default.
- W1606673973 cites W2048486827 @default.
- W1606673973 cites W2048502950 @default.
- W1606673973 cites W2049914044 @default.
- W1606673973 cites W2050638312 @default.
- W1606673973 cites W2051381362 @default.
- W1606673973 cites W2051738169 @default.
- W1606673973 cites W2051797386 @default.
- W1606673973 cites W2052599194 @default.
- W1606673973 cites W2055452454 @default.
- W1606673973 cites W2055807215 @default.
- W1606673973 cites W2056928450 @default.
- W1606673973 cites W2059276463 @default.
- W1606673973 cites W2061556393 @default.
- W1606673973 cites W2061740109 @default.
- W1606673973 cites W2064311965 @default.
- W1606673973 cites W2065168966 @default.
- W1606673973 cites W2069002586 @default.
- W1606673973 cites W2069025840 @default.
- W1606673973 cites W2070006896 @default.
- W1606673973 cites W2070754183 @default.
- W1606673973 cites W2071308352 @default.
- W1606673973 cites W2073051554 @default.
- W1606673973 cites W2073631169 @default.
- W1606673973 cites W2075480738 @default.
- W1606673973 cites W2077714658 @default.
- W1606673973 cites W2078628157 @default.
- W1606673973 cites W2083536525 @default.
- W1606673973 cites W2087296674 @default.
- W1606673973 cites W2087435196 @default.
- W1606673973 cites W2087523259 @default.