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- W1606779997 abstract "The centrosome, which functions as a major microtubule-organizing center (MTOC), is composed of a pair of centrioles and surrounding protein aggregates called pericentriolar material (PCM); at any given time during the cell cycle, each cell contains one or two centrosomes (Fukasawa, 2007). Centrosomes play a crucial role in the formation of bipolar mitotic spindles, which are essential for accurate chromosome segregation (Zyss & Gergely, 2009). Numerical and functional abnormalities of centrosomes result in an increase in aberrant mitotic spindle formation, merotelic kinetochore-microtubule attachment errors, lagging chromosome formation, and chromosome segregation errors, all of which are thought to be possible causes of chromosome instability (Ganem et al., 2009; Nigg & Raff, 2009). Centrosome abnormalities and chromosome instability are characteristics of human lung cancer (Masuda and Takahashi, 2002; Koutsami et al., 2006; Jung et al., 2007; Shinmura et al., 2008), and abnormalities in genes responsible for centrosome regulation have been reported in lung cancer (Fukasawa, 2007; Lee et al., 2010). In this Review, the status of centrosome abnormalities in lung cancer, the mechanisms responsible for inducing centrosome abnormalities, and the relationship between centrosome abnormalities and chromosome instability are summarized." @default.
- W1606779997 created "2016-06-24" @default.
- W1606779997 creator A5000601994 @default.
- W1606779997 creator A5032598140 @default.
- W1606779997 date "2012-03-02" @default.
- W1606779997 modified "2023-10-02" @default.
- W1606779997 title "Centrosome Abnormality and Human Lung Cancer" @default.
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