FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1606994795> ?p ?o ?g. }

• W1606994795 endingPage "295" @default.
• W1606994795 startingPage "289" @default.
• W1606994795 abstract "Chick brain mRNA was isolated and injected into Xenopus oocytes. This led to the expression in the surface membrane of functional GABA- activated channels with properties reminiscent of vertebrate GABAA channels. The GABA-induced current was analyzed quantitatively under voltage-clamp conditions. Picrotoxin inhibited this current in a concentration-dependent manner with IC50 = 0.6 microM. The allosteric modulation of GABA currents by a number of drugs acting at the benzodiazepine binding site was characterized quantitatively. In the presence of the benzodiazepine receptor ligands diazepam and clorazepate, GABA responses were enhanced, and in the presence of the convulsant beta-carboline compound methyl 6,7-dimethoxy-4-ethyl-beta- carboline-3-carboxylate (DMCM), they were depressed. Maximal stimulation of the response elicited by 10 microM GABA was 160% with diazepam and 90% with clorazepate, and maximal inhibition was 42% with DMCM, 30% with methyl beta-carboline-3-carboxylate (beta-CCM), 15% with ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5a][1,4]benzodiazepine-3-carboxylate (Ro 15–1788), and 12% with ethyl beta-carboline-3-carboxylate (beta-CCE). Half-maximal stimulation was observed with 20 nM diazepam and 390 nM clorazepate, respectively, and half-maximal inhibition with 6 nM DMCM. beta-CCM had a similar effect to DMCM, whereas beta-CCE and Ro 15–1788 showed only small inhibition at low concentrations (less than 1 microM). All the tested carboline compounds and Ro 15–1788 showed a biphasic action and stimulated GABA current at concentrations higher than 1 microM." @default.
• W1606994795 created "2016-06-24" @default.
• W1606994795 creator A5000466780 @default.
• W1606994795 creator A5034050688 @default.
• W1606994795 date "1988-01-01" @default.
• W1606994795 modified "2023-10-18" @default.
• W1606994795 title "Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes" @default.
• W1606994795 cites W1528288950 @default.
• W1606994795 cites W1592243888 @default.
• W1606994795 cites W1964813603 @default.
• W1606994795 cites W1979382362 @default.
• W1606994795 cites W1980664472 @default.
• W1606994795 cites W1992688451 @default.
• W1606994795 cites W1994337462 @default.
• W1606994795 cites W2002455415 @default.
• W1606994795 cites W2006367499 @default.
• W1606994795 cites W2011037064 @default.
• W1606994795 cites W2017363078 @default.
• W1606994795 cites W2024251829 @default.
• W1606994795 cites W2029462562 @default.
• W1606994795 cites W2031947493 @default.
• W1606994795 cites W2034882984 @default.
• W1606994795 cites W2047460755 @default.
• W1606994795 cites W2052052892 @default.
• W1606994795 cites W2057155276 @default.
• W1606994795 cites W2060497494 @default.
• W1606994795 cites W2088986997 @default.
• W1606994795 cites W2092603961 @default.
• W1606994795 cites W2104877311 @default.
• W1606994795 cites W2107731277 @default.
• W1606994795 cites W2115047895 @default.
• W1606994795 cites W2126535828 @default.
• W1606994795 cites W2152837451 @default.
• W1606994795 cites W2338346296 @default.
• W1606994795 cites W2416256985 @default.
• W1606994795 doi "https://doi.org/10.1523/jneurosci.08-01-00289.1988" @default.
• W1606994795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6569358" @default.
• W1606994795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2448430" @default.
• W1606994795 hasPublicationYear "1988" @default.
• W1606994795 type Work @default.
• W1606994795 sameAs 1606994795 @default.
• W1606994795 citedByCount "91" @default.
• W1606994795 countsByYear W16069947952012 @default.
• W1606994795 countsByYear W16069947952013 @default.
• W1606994795 countsByYear W16069947952014 @default.
• W1606994795 countsByYear W16069947952016 @default.
• W1606994795 countsByYear W16069947952017 @default.
• W1606994795 countsByYear W16069947952018 @default.
• W1606994795 countsByYear W16069947952019 @default.
• W1606994795 countsByYear W16069947952020 @default.
• W1606994795 countsByYear W16069947952021 @default.
• W1606994795 countsByYear W16069947952022 @default.
• W1606994795 crossrefType "journal-article" @default.
• W1606994795 hasAuthorship W1606994795A5000466780 @default.
• W1606994795 hasAuthorship W1606994795A5034050688 @default.
• W1606994795 hasBestOaLocation W16069947951 @default.
• W1606994795 hasConcept C134018914 @default.
• W1606994795 hasConcept C166342909 @default.
• W1606994795 hasConcept C168258287 @default.
• W1606994795 hasConcept C170493617 @default.
• W1606994795 hasConcept C185592680 @default.
• W1606994795 hasConcept C24998067 @default.
• W1606994795 hasConcept C2776175493 @default.
• W1606994795 hasConcept C2778173252 @default.
• W1606994795 hasConcept C2779324764 @default.
• W1606994795 hasConcept C55493867 @default.
• W1606994795 hasConcept C86803240 @default.
• W1606994795 hasConcept C98274493 @default.
• W1606994795 hasConceptScore W1606994795C134018914 @default.
• W1606994795 hasConceptScore W1606994795C166342909 @default.
• W1606994795 hasConceptScore W1606994795C168258287 @default.
• W1606994795 hasConceptScore W1606994795C170493617 @default.
• W1606994795 hasConceptScore W1606994795C185592680 @default.
• W1606994795 hasConceptScore W1606994795C24998067 @default.
• W1606994795 hasConceptScore W1606994795C2776175493 @default.
• W1606994795 hasConceptScore W1606994795C2778173252 @default.
• W1606994795 hasConceptScore W1606994795C2779324764 @default.
• W1606994795 hasConceptScore W1606994795C55493867 @default.
• W1606994795 hasConceptScore W1606994795C86803240 @default.
• W1606994795 hasConceptScore W1606994795C98274493 @default.
• W1606994795 hasIssue "1" @default.
• W1606994795 hasLocation W16069947951 @default.
• W1606994795 hasLocation W16069947952 @default.
• W1606994795 hasLocation W16069947953 @default.
• W1606994795 hasLocation W16069947954 @default.
• W1606994795 hasOpenAccess W1606994795 @default.
• W1606994795 hasPrimaryLocation W16069947951 @default.
• W1606994795 hasRelatedWork W1919267946 @default.
• W1606994795 hasRelatedWork W2004892812 @default.
• W1606994795 hasRelatedWork W2013536843 @default.
• W1606994795 hasRelatedWork W2020854130 @default.
• W1606994795 hasRelatedWork W2046660718 @default.
• W1606994795 hasRelatedWork W2050790720 @default.
• W1606994795 hasRelatedWork W2055691360 @default.
• W1606994795 hasRelatedWork W2149348217 @default.
• W1606994795 hasRelatedWork W2903207105 @default.
• W1606994795 hasRelatedWork W4298120844 @default.
• W1606994795 hasVolume "8" @default.

• next