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- W1607095906 abstract "Abstract Two phenylimidothiazole salts, racemic tetramisole and l-isomer, levamisole, modulate mouse immune responsiveness. They produce either enhancement or depression of the number of plaque-forming cells (PFC) to sheep red blood cells (SRBC), depending on the dose and on time of administration of the drugs in relation to antigenic stimulus. They can render antigenic a quantity of SRBC which was insufficient in itself to immunize mice. These effects are not accompanied with an increase of serum antibody level. Immunostimulation does not modify the horse red cell background response. Enhanced immune responses are associated to splenocontraction, whereas the number of nucleated cells per spleen remains unchanged. Steric configuration of phenylimidothiazole salts plays a role, in that the d-optic isomer is almost completely devoid of immuno-modifying activities. The possible relationships between immunologic and pharmacologic activities of phenylimidothiazole salts are discussed." @default.
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- W1607095906 date "1974-09-01" @default.
- W1607095906 modified "2023-10-13" @default.
- W1607095906 title "Modulation of Immune Reactivity by Phenylimidothiazole Salts in Mice Immunized by Sheep Red Blood Cells" @default.
- W1607095906 doi "https://doi.org/10.4049/jimmunol.113.3.779" @default.
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