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- W1607134312 endingPage "3273" @default.
- W1607134312 startingPage "3273" @default.
- W1607134312 abstract "The insulin-like growth factor (IGF) ligands stimulate cellular proliferation and survival by activating the type I insulin-like growth factor receptor (IGF-IR). As a result, the IGF signaling system is implicated in a number of cancers, including those of the breast, prostate, and lung. In addition to mitogenic and anti-apoptotic roles that may directly influence tumor development, IGF-IR also appears to be a critical determinant of response to numerous cancer therapies. This review describes the role of the IGF-IR pathway in mediating resistance to both general cytotoxic therapies, such as radiation and chemotherapy, and targeted therapies, such as tamoxifen and trastuzumab. It concludes with a description of approaches to target IGF-IR and argues that inhibition of IGF signaling, in conjunction with standard therapies, may enhance the response of cancer cells to multiple modalities." @default.
- W1607134312 created "2016-06-24" @default.
- W1607134312 creator A5038575318 @default.
- W1607134312 creator A5041977512 @default.
- W1607134312 creator A5062083547 @default.
- W1607134312 creator A5077225386 @default.
- W1607134312 creator A5090729567 @default.
- W1607134312 date "2008-01-01" @default.
- W1607134312 modified "2023-09-27" @default.
- W1607134312 title "The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance" @default.
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